Publications by authors named "R Jokela"
The human gut microbiota is central in regulating all facets of host physiology, and in early life it is thought to influence the host's immune system and metabolism, affecting long-term health. However, longitudinally monitored cohorts with parallel analysis of faecal samples and health data are scarce. In our observational study we describe the gut microbiota development in the first 2 years of life and create a gut microbiota wellbeing index based on the microbiota development and health data in a cohort of nearly 1000 infants using clustering and trajectory modelling.
View Article and Find Full Text PDFArticle Synopsis
- Antibiotic resistance genes (ARGs) are commonly found in the gut microbiota of infants, contributing to a reservoir of ARGs that evolve as the microbiome develops in early life.
- A study analyzing 2,328 stool samples from 475 children revealed that infants share more similar gut ARG compositions with their mothers and spouses than with their fathers, indicating family influences on ARG dynamics.
- The research shows that early gut microbiota development is a significant factor in ARG load, with caesarean-delivered infants having lower ARG levels, highlighting that the typical evolution of gut bacteria has a stronger impact on ARGs than recent antibiotic use.
Background: Propofol is a widely used intravenous hypnotic. Dosing is based mostly on weight, with great interindividual variation in consumption. Suggested factors affecting propofol requirements include age, sex, ethnicity, anxiety, alcohol consumption, smoking, and concomitant valproate use.
View Article and Find Full Text PDFBackground: Although the infant gut microbiota has been extensively studied, comprehensive assessment on the microbiota determinants including technical variables has not been performed in large infant cohorts.
Methods: We studied the effect of 109 variables on the 16S rRNA gene amplicon-based gut microbiota profiles of infants sampled longitudinally from three weeks to two years of life in the Finnish HELMi birth cohort. Spot faecal samples from both parents were included for intra-family analyses, totalling to 7657 samples from 985 families that were evaluated for beta-diversity patterns using permutational multivariate analysis on Bray-Curtis distances, and differential abundance testing and alpha-diversity for variables of interest.
Article Synopsis
- The study investigated the genetic and clinical factors that contribute to post-operative nausea and vomiting (PONV), which affects about 30% of patients despite existing preventive measures.
- Conducted at Helsinki University Hospital, the research involved 815 women undergoing breast cancer surgery, examining genetic variants and their association with PONV through a genome-wide association study (GWAS).
- Results revealed that 35% experienced PONV post-surgery, with significant predictors identified, including age, anesthesia status, and previous history of nausea; the GWAS found six genetic variants potentially linked to PONV.