Assessment and Treatment for Persons with Coexisting Ability and Substance Use Issues: A Review and Analysis of the Literature.

Persons with ability issues are at considerably higher risk to develop substance use problems when compared to the general population. Yet, little is known about the current status of substance use treatment for this population. A comprehensive search of the literature revealed a need for (a) population-specific instruments for screening and assessment of the use of alcohol and drugs, including the misuse of prescription medication; (b) tailored treatment methods and individualized treatment plans that meet diverse literacy or cognitive needs;

Paving a path to inclusion.

Given the Canadian Aboriginal People's colonial legacy of multiple deprivations, the discord between an Aboriginal worldview and the dominant neo-liberal culture in Canada, and the recognized disadvantage vulnerability of single mothers, this quantitative study was aimed at increasing the understanding of exclusion, specifically with reference to the domains of disadvantage of Saskatchewan Aboriginal/Non-Aboriginal single mothers. We conducted a self-administered survey (random selection) of Saskatchewan single mothers (ages 18-59) who had at least one child less than 18 years of age living with them. In our cross-sectional self-administered survey, we compared specific social aspects of life between groups of randomly selected Saskatchewan single mothers, Aboriginal and Non-Aboriginal.

Allostatic load: single parents, stress-related health issues, and social care.

This article explores the possible relationships between allostatic load (AL) and stress-related health issues in the low-income single-parent population, using both a population health perspective (PHP) and a biological framework. A PHP identifies associations among such factors as gender, income, employment, and social support and their potential effect on health outcomes. A PHP also recognizes physiological and pathological manifestations of the body such as stress (mental or somatic) and individual biological parameters (for example, glucose levels) as health determinants.

Biochemical and structural characterization of (South)-methanocarbathymidine that specifically inhibits growth of herpes simplex virus type 1 thymidine kinase-transduced osteosarcoma cells.

Two analogs of the natural nucleoside dT featuring a pseudosugar with fixed conformation in place of the deoxyribosyl residue (carbathymidine analogs) were biochemically and structurally characterized for their acceptance by both human cytosolic thymidine kinase isoenzyme 1 (hTK1) and herpes simplex virus type 1 thymidine kinase (HSV1 TK) and subsequently tested in cell proliferation assays. 3'-exo-Methanocarbathymidine ((South)-methanocarbathymidine (S)-MCT), which is a substrate for HSV1 TK, specifically inhibited growth of HSV1 TK-transduced human osteosarcoma cells with an IC(50) value in the range of 15 microM without significant toxicity toward both hTK1-negative (TK(-)) and non-transduced cells. 2'-exo-Methanocarbathymidine ((North)-methanocarbathymidine (N)-MCT), which is a weak substrate for hTK1 and a substantial one for HSV1 TK, induced a specific growth inhibition in HSV1 TK-transfected cells comparable to that of (S)-MCT and ganciclovir.

The mechanical strength of bones in torsion application to human tibiae.

How strong is a long bone in torsion? The principle of mechanical engineering of torsion on a beam is applied to the cylindrical tube model of a bone. The deformation and the strength of the tube are calculated. The calculated strength is about twice that of a real, not circular bone (human tibia) with the same cross-sectional area.