Publications by authors named "R John Crew"

Introduction: We sought to streamline cataract surgery post-operative care when COVID-19 hit by discontinuing the 1-day post-operative visit. We wanted to know if this change was safe and beneficial to our patients by reducing patients' time and transportation burden, opening appointment slots allowing providers to see more patients and reducing greenhouse gas emissions. By minimising intraoperative use of dispersive viscoelastic, increasing irrigation/aspiration time at the end of the surgery and using intraocular pressure (IOP) lowering medications such as carbachol, brimonidine and acetazolamide routinely, we posit that post-operative day 1 IOP spikes can be avoided, thereby eliminating the need for the 1st post-operative day visit.

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Article Synopsis
  • Dysferlinopathies are a type of muscular dystrophy caused by mutations that lead to a deficiency of the protein dysferlin, resulting in muscle wasting and inflammation, with no available treatments.
  • Glucocorticoids, commonly used for reducing inflammation in muscular dystrophies, have been found to worsen conditions in dysferlinopathy patients by accelerating muscle strength loss.
  • Research on mice with dysferlin deficiency revealed that glucocorticoid treatment exacerbates muscle damage and alters gene expression related to inflammation and metabolism, indicating the need for alternative therapeutic strategies.
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Background: C3 glomerulopathy (C3G), which encompasses C3GN and dense deposit disease (DDD), results from dysregulation of the alternative complement pathway. Data on disease recurrence after kidney transplantation are limited, and details on histologic features of recurrent C3G are scarce. We aimed to evaluate C3G recurrence in the allograft, with a focus on histologic presentation and progression.

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The specific biology of the male breast remains relatively unexplored in spite of the increasing global prevalence of male breast cancer. Delineation of the microenvironment of the male breast is restricted by the low availability of human samples and a lack of characterisation of appropriate animal models. Unlike the mouse, the male ovine gland persists postnatally.

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