Publications by authors named "R Johana Fajardo C"
People with chronic pain mitigate their suffering by the action of opioids. Adverse reactions aside, opioids are not exempt from potential complications like addiction and abuse, which have posed a global public health problem lately. Finding new therapeutic strategies to improve analgesia and to reduce opioid side effects has become a priority.
View Article and Find Full Text PDFNeurological diseases (NDs), including neurodegenerative disorders and acute injuries, are a significant global health concern. The PI3K/Akt/mTOR pathway, a crucial signaling cascade, is responsible for the survival of cells, proliferation, and metabolism. Dysregulation of this pathway has been linked to neurological conditions, indicating its potential as a vital target for therapeutic approaches.
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- Nasal prostheses are vital for patients who have lost part or all of their nose due to various reasons like cancer or accidents, providing a solution for rehabilitation.* -
- A case study highlights a patient with basal cell carcinoma who received a nasal prosthesis made from polymethyl methacrylate, which is securely attached to eyewear for better stability and comfort.* -
- The use of custom coloring and texturing ensures the prosthesis matches the patient's skin, boosting their self-confidence and improving their overall quality of life.*
Article Synopsis
- * A case report discusses a patient with type 2 diabetes who had unusual symptoms that made it hard to diagnose, with initial treatments failing.
- * The use of advanced microbiological methods helped quickly identify the pathogen, leading to effective treatment and stressing the importance of considering melioidosis in severe infection cases, especially for patients with preexisting conditions.
Mechanistic Insights into Tau Protein-Mediated Regulation of Oxidative Stress.
Zhongguo Ying Yong Sheng Li Xue Za Zhi
October 2024
Article Synopsis
- Abnormal tau protein behavior, including hyperphosphorylation and aggregation, is a major feature of tauopathies like Alzheimer's disease, leading to neurodegeneration.
- The interaction between oxidative stress and tau pathology is complex, with both factors contributing to neuronal damage through impaired microtubule stability and transport.
- Further research into oxidative stress sources, such as microglial cells, could improve our understanding of tauopathies and aid in developing new treatment strategies.