Publications by authors named "R Joannides"
Article Synopsis
- The study explores how altered endothelial flow sensitivity related to polycystin deficiency contributes to hypertension in autosomal dominant polycystic kidney disease (ADPKD) patients.
- Nineteen ADPKD patients were treated with the dopamine receptor agonist rotigotine, showing that a higher dose significantly improved nitric oxide release and endothelial function without major changes in overall blood pressure.
- The findings suggest that targeting endothelial dopamine receptors could be a promising new treatment strategy to mitigate cardiovascular issues linked with ADPKD.
Background And Aims: Changes in arterial wall viscosity (AWW) and stiffness during type 2 diabetes (T2D) have been little investigated. We explored changes in carotid AWV considering change in arterial stiffness and loading conditions, in patients with T2D.
Methods: This cross-sectional, monocentric study compared 19 middle-aged patients with T2D to 30 non-diabetic (ND) controls.
Article Synopsis
- Type 2 diabetes (T2D) and hypertension (HTN) are linked to cardiovascular diseases and involve chronic inflammation and poor endothelial function.
- The study looked at how HTN and T2D affect levels of certain arachidonic acid metabolites in plasma, using advanced chromatography and mass spectrometry on 44 patients.
- Results showed no significant changes in T2D patients compared to healthy ones, but HTN was linked to altered metabolite patterns, especially with different hydroxyeicosatrienoic acids (HETE). Further research is needed on how these changes might influence glucose and insulin regulation.
Background Changes in arterial wall viscosity, which dissipates the energy stored within the arterial wall, may contribute to the beneficial effect of heart rate (HR) reduction on arterial stiffness and cardiovascular coupling. However, it has never been assessed in humans and could be altered by aging. We evaluated the effect of a selective HR-lowering agent on carotid arterial wall viscosity and the impact of aging on this effect.
View Article and Find Full Text PDFIntravenous (i.v.) morphine is a safe, robust, and recommended treatment for severe pain using the titration principle.
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