Publications by authors named "R Jimenez-Saiz"
Allergic reactions to foods are primarily driven by allergen-binding immunoglobulin (Ig)E antibodies. IgE-expressing cells can be generated through direct switching from IgM to IgE or a sequential class switching pathway where activated B cells first switch to an intermediary isotype, most frequently IgG1, and then to IgE. It has been proposed that sequential class switch recombination is involved in augmenting the severity of allergic reactions, generating high affinity IgE, differentiation of IgE plasma cells, and in holding the memory of IgE responses.
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- The gut microbiome is crucial for our body's functioning, but the effects of non-nutritious food components on it are often ignored.
- Certain food additives and microplastics may negatively impact the gut microbiome and human health, and understanding the mechanisms behind this is essential.
- Recommendations include integrating gut microbiome research into food safety assessments to better evaluate the risks of food additives and contaminants.
Article Synopsis
- - CXCR4 is a chemokine receptor that plays key roles in immune cell movement, organ development, and various diseases, including cancer and HIV-1 infection, with only one blocker, plerixafor, currently used clinically.
- - Recent research shows that when activated by CXCL12, CXCR4 changes its structure, reducing membrane-bound units and forming larger immobile clusters necessary for cells to respond to chemical signals.
- - Using molecular modeling, scientists discovered a compound, AGR1.137, that disrupts these CXCR4 clusters without interfering with CXCL12 binding, effectively blocking cellular response to chemical gradients in laboratory settings.
Article Synopsis
- - EFSA was asked by the European Commission to evaluate the safety and regulation of new biotech developments (NGTs) applied to microorganisms for environmental release and food/feed use.
- - A study found that NGT-modified microorganisms are not expected to pose new risks compared to those modified through older genetic methods, suggesting NGTs might lead to fewer hazards overall.
- - EFSA's existing guidelines are deemed "partially applicable," meaning some aspects can be simplified for NGTs, but updates are needed for better risk assessment across all genetic modification methods.