Genetic deletion of G protein-coupled receptor 56 aggravates traumatic brain injury through the microglial CCL3/4/5 upregulation targeted to CCR5.

Traumatic brain injury (TBI) is a significant global health concern that often results in death or disability, and effective pharmacological treatments are lacking. G protein-coupled receptor 56 (GPR56), a potential drug target, is crucial for neuronal and glial cell function and therefore plays important roles in various neurological diseases. Here, we investigated the potential role and mechanism of GPR56 in TBI-related damage to gain new insights into the pharmacological treatment of TBI.

Discovery of a novel quinoline RIP1 inhibitor and its treatment of acute liver injury in mice.

Necroptosis is closely associated with the development of inflammatory diseases, including acute liver injury. However, the precise role of necroptosis-related signature proteins in acute liver injury remains incompletely understood. Previously, our group investigated Compound o1, a RIP1 inhibitor, but its antinecroptosis activity and RIP1 binding affinity were suboptimal.

Construction and preliminary trial test of a decision-making app for pre-hospital damage control resuscitation.

Purpose: To construct a decision-making app for pre-hospital damage control resuscitation (PHDCR) for severely injured patients, and to make a preliminary trial test on the effectiveness and usability aspects of the constructed app.

Methods: Decision-making algorithms were first established by a thorough literature review, and were then used to be learned by computer with 3 kinds of text segmentation algorithms, i.e.

Effects of different sources of lactoferrin on cytokine response to SARS-COV-2, respiratory syncytial virus, and rotavirus infection in vitro.

Lactoferrin (Lf) is a multifunctional iron-binding glycoprotein, involved in a wide range of bioactivities, including immunomodulatory and antiviral activities. Lf in human milk and bovine Lf added to infant formula may provide some protection against viral infections. However, functions of Lfs from different sources may differ due to varying manufacturing processes and posttranslational modifications.

Aluminum and microplastic release from reflective agricultural films disrupt microbial communities and functions in soil.

Reflective agricultural films are widely used in vegetable production and orchards to repel pests, accelerate fruit ripening, and boost yields. These films, composed of a plastic base metallized with aluminum (Al), degrade over time in soil, releasing Al and microplastics. This study investigated the aging and weathering of Al-coated reflective films (polyethylene terephthalate, PET-based) under UV radiation, simulated rainfall, and soil burial for up to 120 days, assessing the effects of released Al and microplastics on soil chemistry and microbial communities.