Publications by authors named "R Jelinek"
Staphylococcus aureus is a major cause of infections like bacteremia, pneumonia, and endocarditis. These infections are often linked to the ability of S. aureus to form biofilms.
View Article and Find Full Text PDFFoodborne pathogens such as , and pose significant risks to human health. The World Health Organization estimates that 2.2 million deaths per year are directly caused by foodborne and waterborne bacterial diseases worldwide.
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- Surface states in gallium nitride (GaN) devices create instability due to surface-charge-trapping, similar to challenges faced by early silicon field effect transistors.
- Unlike silicon, which found solutions through oxygen and hydrogen passivation, GaN lacks a breakthrough method to address this issue.
- Study reveals that heat treatment in vacuum can remove surface charge, but re-adsorption occurs when exposed to air, specifically pointing to nitric oxide (NO) as a key factor influencing the surface charge that impacts GaN's electrical properties.
Coassembly of peptide biomaterials offers a compelling avenue to broaden the spectrum of hierarchically ordered supramolecular nanoscale structures that may be relevant for biomedical and biotechnological applications. In this work coassemblies of amphiphilic and oppositely charged, anionic and cationic, β-sheet peptides are studied, which may give rise to a diverse range of coassembled forms. Mixtures of the peptides show significantly lower critical coassembly concentration (CCC) values compared to those of the individual pure peptides.
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- Glucagon, a vital peptide hormone, regulates blood glucose and lipid metabolism, and its amyloid fibrils have been found to catalyze biological reactions such as esterolysis and lipid hydrolysis.
- Recent experiments using quantum mechanics/molecular mechanics simulations revealed the catalytic mechanism of these fibrils in the esterolysis of -nitrophenyl acetate, involving critical proton transfer and nucleophilic attack steps.
- The study's findings show a close match between calculated and experimental reaction barriers, confirming the catalytic role of glucagon amyloid fibrils and enhancing our understanding of their biological function.