Publications by authors named "R Jans"
Article Synopsis
- Individuals with psychotic disorders are at higher risk of victimization, prompting the development of a new therapy called BEATVIC to prevent such incidents, which was tested in a randomized controlled trial with 105 participants.
- The trial compared the BEATVIC intervention with befriending sessions, aiming to measure short-term effects on victimization risk factors and overall well-being, finding that 60% of participants in both groups experienced reduced victimization after six months.
- Despite the initial success in reducing victimization, BEATVIC did not show greater effectiveness compared to befriending, and no additional positive changes in risk factors were observed, indicating the need for further long-term analysis.
Due to the COVID-19 pandemic, laboratories have faced unprecedented demand for in-home delivery test services. This drastic demand increase requires a rapid reaction from laboratories to manage their testers in order to respond to the high demand volume and avoid unnecessary costs. This study provides an optimization model based on the vehicle routing problem with time windows by considering the testers' workload balancing to improve laboratories' assignment and routing policies.
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- The study investigates how mesenchymal stromal cells (MSCs) undergo changes during culture that affect their growth and differentiation, which is tied to cellular aging.
- The researchers developed an Epigenetic-Senescence-Signature based on DNA methylation at six specific CpG sites, helping to predict the state of cellular aging in MSCs.
- Results showed a good correlation between predicted and actual cellular aging parameters, indicating that this epigenetic analysis could serve as a useful quality control tool for therapeutic cell preparations.
AP1 (jun/fos) transcription factors (c-jun, junB, junD, c-fos, FosB, Fra-1, and Fra-2) are key regulators of epidermal keratinocyte survival and differentiation and important drivers of cancer development. Understanding the role of these factors in epidermis is complicated by the fact that each protein is expressed, at different levels, in multiple cells layers in differentiating epidermis, and because AP1 transcription factors regulate competing processes (i.e.
View Article and Find Full Text PDFLysophosphatidic acid (LPA) enhances cell migration and promotes wound healing in vivo, but the intracellular signaling pathways regulating these processes remain incompletely understood. Here we investigated the involvement of agonist-induced Ca(2+) entry and STIM1 and Orai1 proteins in regulating nuclear factor of activated T cell (NFAT) signaling and LPA-induced keratinocyte cell motility. As monitored by Fluo-4 imaging, stimulation with 10 μM LPA in 60 μM Ca(2+)(o) evoked Ca(2+)(i) transients owing to store release, whereas addition of LPA in physiological 1.
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