Publications by authors named "R Jaganathan"

Electronic cigarettes (e-cigarettes) have emerged as a potential alternative to traditional smoking and may aid in tobacco harm reduction and smoking cessation. E-cigarette use has notably increased, especially among young non-tobacco users, raising concerns due to the unknown long-term health effects. The oral cavity is the first and one of the most crucial anatomical sites for the deposition of e-cigarette aerosols.

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The challenge with breast cancer is its ongoing high prevalence and difficulties in early detection and access to effective care. A solution lies in creating tailored metal-organic frameworks to encapsulate anticancer drugs, enabling precise and targeted treatment with less adverse effects and improved effectiveness. Zeolitic imidazolate framework-8 (ZIF-8) and carboplatin (CP)-loaded ZIF-8 were synthesized and characterized using various analytical techniques.

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Article Synopsis
  • Lung cancer treatment faces challenges due to non-specificity and damage to healthy cells, but nanoparticle-based drug delivery systems (NDDSs) offer potential solutions.
  • Extracellular vesicles (EVs), particularly those isolated from human umbilical endothelial cells (HUVECs), can evade immune responses and deliver drugs with minimal toxicity.
  • In this study, engineered GE11-HUVEC-EVs were loaded with the drug vinorelbine and demonstrated effective tumoricidal effects in lung cancer models, targeting cells that overexpress the epidermal growth factor receptor (EGFR).
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Cyanobacteria are resilient microorganisms and thrive in environments exposed to UV radiation, ranging from ocean surfaces to scorching hot springs and dry expanses. 'Cyanobacterial Resilience' refers to their ability to withstand UV radiation, revealing intricate genomic secrets and adaptive mechanisms ensuring survival. These mechanisms include metabolic adaptations, robust DNA repair systems and UV-protective compounds such as Scytonemin and Mycosporine, vital for shielding against UV radiation survival.

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Article Synopsis
  • - This study explores how well the Furin enzyme interacts with two inhibitors, Naphthofluorescein and CMK, using techniques like molecular docking and molecular dynamics simulations.
  • - Molecular docking indicated that CMK has a stronger binding affinity (-9.18 kcal/mol) compared to Naphthofluorescein (-5.39 kcal/mol), but MD simulations showed CMK's binding was unstable.
  • - In contrast, Naphthofluorescein showed better stability and consistent interactions with Furin during the simulations, suggesting it may be a more effective inhibitor, potentially useful for COVID-19 treatment pending further studies.
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