Publications by authors named "R J.W. de Keizer"
Article Synopsis
- Therapeutic drug monitoring (TDM) for biologic therapies in inflammatory bowel disease (IBD) focuses on optimizing medication doses but faces challenges like identifying ideal drug levels and dealing with variability in drug response.
- Recent advancements, including population pharmacokinetic/pharmacodynamic (PK/PD) modeling and model-informed precision dosing (MIPD) tools, as well as point-of-care testing and new software, present promising solutions to these challenges.
- Implementing these innovations could lead to personalized dosing strategies, moving away from the current one-size-fits-all approach that doesn't meet the diverse needs of IBD patients.
Background: For the selective detection of thyroid-stimulating hormone receptor antibodies with stimulating properties (thyroid-stimulating immunoglobulins; TSI), a novel and rapid bioassay (Turbo TSI) has been introduced. We evaluate the clinical performance of Turbo TSI in Graves' orbitopathy (GO) patients and compare it to a bridge-based TSI binding immunoassay and third generation TSH-R-binding inhibitory immunoglobulins (TBII) assay. Also, we investigate the association of Turbo TSI and TBII measurements with GO activity and severity, as well as response to intravenous methylprednisolone (IVMP), and compare results to previous findings on the bridge-based TSI binding immunoassay.
View Article and Find Full Text PDFPurpose: We aimed to develop and evaluate a population PK model of mycophenolic acid (MPA) in pediatric kidney transplant patients to aid MPA dose optimization.
Methods: Data were collected from pediatric kidney transplant recipients from a Dutch academic hospital (Radboudumc, the Netherlands). Pharmacokinetic model-building and model-validation analyses were performed using NONMEM.
Background/aims: Data regarding the effectiveness of prophylactic systemic antibiotics (PSA) in lacrimal surgery is scarce. Therefore, we determined the postoperative surgical site infection (SSI) rate in lacrimal surgery without PSA.
Methods: We retrospectively analysed files of patients who underwent external (extDCR) or endoscopic endonasal dacryocystorhinostomy (endoDCR).
Background: Both parametric and nonparametric methods have been proposed to support model-informed precision dosing (MIPD). However, which approach leads to better models remains uncertain. Using open-source software, these 2 statistical approaches for model development were compared using the pharmacokinetics of vancomycin in a challenging subpopulation of class 3 obesity.
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