Publications by authors named "R J Tufano"
Background: This study evaluates the utility of PTeye autofluorescence (AF) technology in primary hyperparathyroidism (PHPT) surgery.
Methods: A retrospective review analyzed 232 patients undergoing first-time parathyroid surgery between September 2021 and 2023. Of these, 92 underwent surgery consecutively without PTeye assistance, then 140 underwent PTeye-guided surgery consecutively.
Background: Recent studies have highlighted the importance of the cell-free DNA (cfDNA) methylation profile in detecting breast cancer (BC) and its different subtypes. We investigated whether plasma cfDNA methylation, using cell-free Methylated DNA Immunoprecipitation and High-Throughput Sequencing (cfMeDIP-seq), may be informative in characterizing breast cancer in patients with BRCA1/2 germline mutations for early cancer detection and response to therapy.
Methods: We enrolled 23 BC patients with germline mutation of BRCA1 and BRCA2 genes, 19 healthy controls without BRCA1/2 mutation, and two healthy individuals who carried BRCA1/2 mutations.
Article Synopsis
- The management of thyroid conditions is changing, focusing on locoregional therapies like ablation and embolization for both benign and malignant cases.
- An international panel of experts is prioritizing research to fill gaps in knowledge regarding minimally invasive treatments for thyroid disease, especially for papillary thyroid microcarcinoma and Stage T1b cancer.
- The panel recommends developing registries and conducting clinical trials to study nodule characteristics and compare treatment options for large functioning nodules, aiming to improve patient outcomes.