Publications by authors named "R J Swart"
Purpose: Artificial intelligence (AI) applications in radiotherapy (RT) are expected to save time and improve quality, but implementation remains limited. Therefore, we used implementation science to develop a format for designing an implementation strategy for AI. This study aimed to (1) apply this format to develop an AI implementation strategy for our center; (2) identify insights gained to enhance AI implementation using this format; and (3) assess the feasibility and acceptability of this format to design a center-specific implementation strategy for departments aiming to implement AI.
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- Swine influenza A viruses (IAVsw) pose a health risk to both pigs and humans, showing varied levels of pathogenicity.
- Researchers created airway organoids from pig bronchus tissue to establish a model for testing the virulence of different IAVsw strains.
- In this model, the H3N2 strain caused more damage to lung cell structures than H1N2 or H1N1 strains, indicating the model's effectiveness for studying IAVsw virulence.
Article Synopsis
- Scientists established a direct-contact transmission model for the SARS-CoV-2 Omicron BA.5 variant using Syrian hamsters, which are highly susceptible to the virus.
- The research involved testing different inoculation doses and co-housing durations to ensure reliable transmission and comparing viral loads and tissue damage between infected donor and naïve recipient hamsters.
- Results indicated that while both male and female hamsters could be infected similarly, males shed significantly more infectious virus; overall, the Omicron BA.5 variant resulted in lower viral loads and less severe symptoms compared to prior strains, highlighting the model's potential for studying new treatment strategies.
Background: Measles is a highly contagious disease presenting a significant risk for unvaccinated infants and adults. Measles vaccination under the age of 12 months provides early protection, but has also been associated with blunting of antibody responses to subsequent measles vaccinations and assumed to have lower vaccine effectiveness.
Methods: Our study included children who received an early measles, mumps and rubella (MMR) vaccination between 6 and 12 months of age (n=79, given in addition to the regular MMR vaccination schedule at 14 months and 9 years) and a group without additional early vaccination (n=44).
Highly pathogenic avian influenza (HPAI) H5N1 viruses are responsible for disease outbreaks in wild birds and poultry, resulting in devastating losses to the poultry sector. Since 2020, an increasing number of outbreaks of HPAI H5N1 was seen in wild birds. Infections in mammals have become more common, in most cases in carnivores after direct contact with infected birds.
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