Publications by authors named "R J Strawbridge"
Whether depression and poor sleep interact or have statistically independent associations with brain structure and its change over time is not known. Within a subset of UK Biobank participants with neuroimaging and subjective and/or objective sleep data (n = 28,351), we examined associations between lifetime depression and sleep disruption and their interaction with structural neuroimaging measures, both cross-sectionally and longitudinally. Sleep variables were: self-reported insomnia and difficulty getting up; actigraphy-derived short sleep (<7 h); sustained inactivity bouts during daytime (SIBD); and sleep efficiency.
View Article and Find Full Text PDFBackground: England's primary care service for psychological therapy (Improving Access to Psychological Therapies [IAPT]) treats anxiety and depression, with a target recovery rate of 50%. Identifying the characteristics of patients who achieve recovery may assist in optimizing future treatment. This naturalistic cohort study investigated pre-therapy characteristics as predictors of recovery and improvement after IAPT therapy.
View Article and Find Full Text PDFBackground: The link between cardiometabolic disease and mental illness has been well established but remains incompletely explained. One hypothesis suggests that circadian rhythm dysregulation links cardiometabolic disease and mental illnesses. is a circadian rhythm regulatory gene.
View Article and Find Full Text PDFArticle Synopsis
- - Immune dysregulation is believed to play a role in affective disorders, and inflammatory biomarkers may help improve or predict outcomes from cognitive remediation therapies (CRT) in bipolar disorder patients.
- - A study involving 44 euthymic adults with bipolar disorder compared the effects of CRT and treatment as usual (TAU) on nine candidate biomarkers related to cognition and psychosocial functioning after 12 weeks of intervention.
- - Results indicated that CRT led to less reduction in certain neurotrophic factors compared to TAU, and participants with lower baseline levels of these factors tended to have better outcomes from CRT, suggesting possible protective effects of the therapy that merit further research.
Background: Many studies have explored whether individual plasma protein biomarkers improve cardiovascular disease risk prediction. We sought to investigate the use of a plasma proteomics-based approach in predicting different cardiovascular outcomes.
Methods: Among 51 859 UK Biobank participants (mean age, 56.