Basic Clin Pharmacol Toxicol
January 2025
In a 2022 consultation, the UK public highlighted the need to disseminate trial results to participants. We assess whether the information provided to trial participants in publicly available participant information sheets (PISs) of trials conducted in the UK is helpful for future trials. This cross-sectional study is based on a search conducted on 18 August 2023 on ClinicalTrials.
View Article and Find Full Text PDFQ J Exp Psychol (Hove)
December 2024
Introduction: Swearing has been linked to increased strength performance (Stephens et al., 2022) and state disinhibition (Hirsch et al, 2011) may be the mechanism linking swearing and strength. Error-related negativity (ERN) is a neural signal associated with response monitoring.
View Article and Find Full Text PDFSARS-CoV-2 is a highly transmissible virus that causes COVID-19 disease. Mechanisms of viral pathogenesis include excessive inflammation and viral-induced cell death, resulting in tissue damage. Here we show that the host E3-ubiquitin ligase TRIM7 acts as an inhibitor of apoptosis and SARS-CoV-2 replication via ubiquitination of the viral membrane (M) protein.
View Article and Find Full Text PDFTraditionally, patients with asymptomatic, advanced-stage follicular lymphoma were managed with a watchful-waiting approach until disease progression. The 'Watch and Wait' Phase-3 randomised international trial examined whether rituximab could delay the need for treatment and the effect on quality of life (QoL). In this article, we present the long-term results of the QoL aspect of the trial.
View Article and Find Full Text PDFSwearing, or using taboo language with the potential to offend, has been shown to improve physical performance during short and intense tasks requiring strength and power development. While consistent ergogenic effects of swearing have been observed across studies, the mechanisms by which swearing impacts physical performance are not fully clear. Swearing has been shown to modulate physiological (i.
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