Publications by authors named "R J Spiegel"
There has been a significant interest in venous congestion in recent years, among which the VExUS score has been prominent, both in clinical practice and research efforts. We have noted some recurrent misconceptions among clinicians which are also reflected in certain research efforts. Notably, the misguided attempt to correlate VExUS to volume status, which is only one of the factors influencing it, as well as attempts to re-interpret VExUS in the context of certain pathologies, which reflects a fundamental misunderstanding of its circulatory perspective.
View Article and Find Full Text PDFThe BOOST-2 trial indicated that optimising brain oxygen (PbtO2) could be a viable therapeutic target for severe traumatic brain injury (sTBI). Previous studies have suggested the safety of airway pressure release ventilation (APRV) in sTBI patients, but its effect on PbtO2 has not been demonstrated. This study is aimed to show that APRV can improve PbtO2 in sTBI patients.
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- * Out of 412 newborns flagged positive for IVA in a large screening in Israel, 371 were false positives, and only 38 confirmedIVA—with 32% being symptomatic and 68% asymptomatic, many of whom have a specific mild variant.
- * The study introduced a new screening algorithm that better distinguishes between symptomatic and asymptomatic cases, aiming to reduce unnecessary treatment and focus on those at higher risk for severe outcomes.
Article Synopsis
- - Smith-Magenis Syndrome (SMS) is a rare genetic disorder linked to intellectual disability, behavioral issues, and sleep problems, caused by a deletion in the chromosome band 17p11.2 affecting the RAI1 gene.
- - RAI1 plays a role in neurodevelopment and may be connected to Parkinson's disease (PD), which is characterized by motor symptoms like tremors and bradykinesia.
- - A case study of a patient with both SMS and early-onset PD raises questions about the relationship between RAI1 gene variations and PD, highlighting the need for more research and attention from caregivers regarding potential PD symptoms in SMS patients.