Publications by authors named "R J Sim"
Aims: To determine the relationship between microbiome dysbiosis indices and biofilm immunogenicity and their prognostic implications on periodontal treatment response.
Materials And Methods: Thirty periodontally healthy controls and 30 periodontitis cases (stage III) were recruited. Cases received non-surgical periodontal therapy (NSPT), and their treatment response at 6 months was evaluated using a treat-to-target endpoint (≤ 4 sites with probing depths ≥ 5 mm).
Exogenous nitrate ingestion can improve exercise performance. This study investigated whether an isotonic beetroot drink could improve jump and sprint performance in active individuals. Twenty-three physically active participants (17 males, 6 females) (mean ± SD; age: 26 ± 4 years; body mass index: 22.
View Article and Find Full Text PDFObjective: To examine factors associated with fertility following hysterosalpingography (HSG) using an oil-soluble contrast medium (OSCM).
Design: In a prospective cohort study on 196 women undergoing OSCM HSG, we showed that iodine excess was almost universal (98%) and mild subclinical hypothyroidism was frequent (38%). Here, we report the analyses of secondary outcomes examining factors associated with the likelihood of pregnancy following the HSG.
Aim: Young-onset type 2 diabetes (YOD) is associated with poorer clinical outcomes. To support the development of more effective diabetes self-management education (DSME) programmes, this study aimed to understand the preferences of young adults with YOD in relation to the modality, content and qualities of DSME.
Methods: Maximal variation sampling was employed to recruit participants of varied age, ethnicity and marital status.
Article Synopsis
- The classical pathway of the complement system is initiated when C1q binds to target activators, including immune complexes, while factor H primarily regulates the alternative pathway but can also influence the classical pathway by competing for binding sites with C1q.
- Both C1q and factor H can recognize and bind to foreign or altered-self materials, including fibrin clots, which can activate the classical complement pathway through mechanisms involving FXIIIa.
- The study showed that fibrin clots do indeed activate the classical pathway, leading to complement activation, but factor H effectively downregulates this activation, highlighting the complex interplay between the complement and coagulation systems.