Can screening and decontamination procedures performed on an outpatient basis reduce the colonization with Staphylococcus aureus and mitigate associated complications in patients undergoing elective hospital procedures? A controlled intervention study (STAUfrei).

Background: Staphylococcus aureus (SA) colonisation increases the risk of wound infections in surgical procedures. Prevention strategies to date have focused primarily on the hospital, although there are recommendations for pre-hospital decontamination at home, which can be performed by patients themselves. The current study aimed to shift the process of screening and decontamination of SA (methicillin-resistant S.

MMP-2 inhibition attenuates ER stress-mediated cell death during myocardial ischemia-reperfusion injury by preserving IRE1α.

Endoplasmic reticulum (ER) stress is one of the major events accompanying myocardial ischemia-reperfusion (IR) injury, as hypoxia and oxidative stress disrupt protein folding in the ER. As a result, the unfolded protein response (UPR) is activated through different sensors including inositol-requiring enzyme 1α (IRE1α) and protein kinase R-like ER kinase (PERK). Failure of the UPR to reduce ER stress induces cellular dysfunction.

From a P-Bridging Phosphaketene to μ-Phosphinidenide and μ-Diphosphaurea Units at a Dinickel Core.

Salt metathesis of dinickel(II) complex LNiBr (1; L is a dinucleating pyrazolate ligand with two β-diketiminato chelate arms) with Na(OCP) ⋅ (dioxane) yielded LNi(PCO) (2) with a P-bridging phosphaethynolate. Further reaction of 2 with benzyl isocyanide or with an N-heterocyclic carbene (NHC) triggered decarbonylation and gave LNi(PCN-CHPh) (3) and LNiP(NHC) (4) with P-bridging cyanophosphide and NHC-phosphinidenide, respectively. Electronic structure analysis indicated a μ-η : η binding mode of the PCO anion between the two Ni ions in 2, which is even more pronounced for the [PCN(-CHPh)] anion in 3.

Trimodality Therapy Versus Radical Cystectomy for Muscle-invasive Bladder Cancer: A Systematic Review and Meta-analysis of Matched Cohort Studies.

Background And Objective: Radical cystectomy (RC) is the standard treatment for muscle-invasive bladder cancer (MIBC). It is highly invasive and associated with perioperative risks, while bladder-preserving trimodality therapy (TMT) offers a less invasive alternative with preferable quality of life for selected patients. We aimed to compare oncological outcomes of TMT and RC in MIBC patients, and evaluate TMT-specific outcomes.

EDITORIAL for BJP themed issue "noncoding RNA therapeutics".

This article is part of a themed issue Non-coding RNA Therapeutics. To view the other articles in this section visit http://onlinelibrary.wiley.