Publications by authors named "R J Sayers"

Article Synopsis
  • - The review aimed to create a comprehensive list of outcome measures for studies on intermittent claudication, with the goal of establishing a standardized core outcome set.
  • - A total of 4985 studies were screened, resulting in 408 included studies that reported 541 unique outcomes categorized by Dodd's domains, highlighting a predominance of clinical-oriented measures.
  • - The findings revealed significant variability in how outcomes are defined across studies, indicating the need for a core outcome set to enhance clarity and consistency in future research on intermittent claudication.
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Objective: Patient characteristics and patterns of disease in chronic limb threatening ischaemia (CLTI) have markedly changed in recent years. Urgent specialist referral and timely revascularisation are recommended in international guidelines. UK guidelines now recommend revascularisation within five days of referral for inpatients and two weeks in outpatients.

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Peripheral artery disease (PAD) is the lower limb manifestation of systemic atherosclerotic disease. PAD may initially present with symptoms of intermittent claudication, whilst chronic limb-threatening ischaemia (CLTI), the end stage of PAD, presents with rest pain and/or tissue loss. PAD is an age-related condition present in over 10% of those aged ≥65 in high-income countries.

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