Publications by authors named "R J Poppiti"
Article Synopsis
- Desmoplastic small round cell tumors (DSRCTs) are rare and aggressive soft tissue sarcomas primarily found in the gastrointestinal tract, believed to stem from mesenchymal stem cells.
- Diagnosing DSRCTs is challenging due to their similarity to other tumors, requiring the use of immunohistochemical staining and molecular analysis for accurate identification.
- Their prognosis varies based on tumor location and stage, often necessitating a multidisciplinary treatment approach that may include surgery, chemotherapy, and radiation therapy.
Hydatidiform moles, including both complete and partial moles, constitute a subset of gestational trophoblastic diseases characterized by abnormal fertilization resulting in villous hydrops and trophoblastic hyperplasia with or without embryonic development. This involves chromosomal abnormalities, where one or two sperms fertilize an empty oocyte (complete hydatidiform mole (CHM); mostly 46,XX) or two sperms fertilize one oocyte (partial hydatidiform mole (PHM); mostly 69,XXY). Notably, recurrent occurrences are associated with abnormal genomic imprinting of maternal effect genes such as (chromosome 19q13.
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- Localized cystic kidney disease (LCKD) is a specific kidney disorder marked by cysts in certain kidney areas, demonstrated in a case of a 41-year-old man with urinary symptoms and hematuria.
- Initial diagnosis revealed a urinary tract infection, but follow-up imaging showed a concerning 2.6 cm cystic lesion in the right kidney, leading to surgical intervention.
- The report highlights LCKD's benign nature, differences from progressive renal diseases, various symptoms, diagnostic methods, and similarities in tissue findings with conditions like polycystic kidney disease.
The Journal retracts the article, Histopathologic Findings Associated with Miller-Dieker Syndrome: An Autopsy Report [...
View Article and Find Full Text PDFClinical Significance of SOX10 Expression in Human Pathology.
Curr Issues Mol Biol
December 2023
The embryonic development of neural crest cells and subsequent tissue differentiation are intricately regulated by specific transcription factors. Among these, , a member of the gene family, stands out. Located on chromosome 22q13, the gene encodes a transcription factor crucial for the differentiation, migration, and maintenance of tissues derived from neural crest cells.
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