Publications by authors named "R J Pariser"
Key Clinical Message: Merkel cell carcinoma (MCC) presents challenges in surveillance due to varied recurrence rates and uncertain follow-up protocols, especially in late recurrent cases. These cases need personalized monitoring strategies beyond traditional timelines, such as clinical and molecular factors, in order to optimize patient outcomes.
Abstract: Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer with neuroendocrine differentiation with a propensity for recurrence following initial treatment.
Article Synopsis
- Hailey-Hailey disease (HHD) is a rare genetic skin condition caused by a mutation in the ATP2C1 gene, leading to skin erosions mainly in sweat-prone areas.
- A particular case examined involved a middle-aged woman with severe, widespread HHD that was resistant to treatment, which ultimately led to her death.
- Diagnosis was confirmed through tissue samples and genetic testing, revealing a specific mutation; there is a need for greater awareness to enhance patient care for this rare variant of HHD.
Background: Non-melanoma skin cancer (NMSC) is highly prevalent in the United States, with darker-skinned patients (DSP) exhibiting lower incidence but increased morbidity and mortality. The purpose of this study is to elucidate NMSC disparities between DSP (Fitzpatrick skin phototype IV or more) and lighter-skinned patients (LSP, Fitzpatrick skin phototype III or less), focusing on surgical features of non-Mohs micrographic surgery-treated NMSC.
Methods: This retrospective cohort study included LSP and DSP diagnosed with either basal cell carcinoma (BCC) or squamous cell carcinoma (SCC) in an academic dermatology setting.