Publications by authors named "R J Osborne"
Although not assessed in standard ecotoxicological tests, exposure to a toxicant that does not result in an observable adverse effect in the parents may lead to transgenerational effects. These are adverse effects observed in unexposed offspring as a result of their parents' exposure to a toxicant. The goal of this study was to investigate whether transgenerational effects are observed in freshwater snails exposed to a toxicant.
View Article and Find Full Text PDFArticle Synopsis
- The study examines four common health literacy instruments—TOFHLA, NVS, HLS-EU-Q47, and HLQ—to compare their effectiveness and reliability in measuring health literacy, noting that health literacy has become more about the interactive relationship between individuals and health systems rather than just individual skills.
- Researchers found high internal consistency across all instruments, but observed notable floor and ceiling effects, with TOFHLA showing the highest ceiling effect and NVS the only floor effect.
- The results indicated low to moderate correlations between the different instruments, suggesting they assess different aspects of health literacy; therefore, the choice of instrument should align with the specific goals of the measurement.
Background: Young children from low-income families experience disparities in school readiness that impact short and long-term health. Family physical activity co-participation is an interactive activity that may promote positive health and academic outcomes. The purpose of this study is to describe the process and outcomes of engaging with community leaders to co-design the Families Moving Together intervention for low-income mothers and their preschool-aged children.
View Article and Find Full Text PDFBackground: Many patients with non-small cell lung cancer (NSCLC) lack access to highly effective approved targeted therapeutics due to multiple gaps in biomarker testing. Challenges in comprehensive molecular testing include complexities associated with the need to assess the presence of multiple variants, costs of running multiple sequential assays per sample, high assay quality control (QC) failure rates, clinical need for rapid turn-around time (TAT) to initiate therapy, and insufficient tissue samples. The ASPYRE-Lung NSCLC assay addresses gaps in multiplexed testing by simultaneously analyzing DNA and RNA, detecting 114 actionable genomic variants across 11 genes, consistent with current NSCLC treatment guidelines.
View Article and Find Full Text PDF