Age is just a number: long-lasting T-cell immunity can span several lifetimes.

T-cell memory is considered long-lasting, but new evidence recently published in Nature by Soerens et al. shows that, under certain conditions, mouse memory T-cell immunity can span several mouse lifetimes.

Single-Cell Transcriptomics Reveals Discrete Steps in Regulatory T Cell Development in the Human Thymus.

CD4CD25FOXP3 regulatory T (Treg) cells control immunological tolerance. Treg cells are generated in the thymus (tTreg) or in the periphery. Their superior lineage fidelity makes tTregs the preferred cell type for adoptive cell therapy (ACT).

GPA33 is expressed on multiple human blood cell types and distinguishes CD4 central memory T cells with and without effector function.

The Ig superfamily protein glycoprotein A33 (GPA33) has been implicated in immune dysregulation, but little is known about its expression in the immune compartment. Here, we comprehensively determined GPA33 expression patterns on human blood leukocyte subsets, using mass and flow cytometry. We found that GPA33 was expressed on fractions of B, dendritic, natural killer and innate lymphoid cells.

Separating the wheat from the chaff: Making sense of Treg heterogeneity for better adoptive cellular therapy.

Regulatory T (Treg) cells are essential for immunological tolerance and can be used to suppress unwanted or excessive immune responses through adoptive cellular therapy. It is increasingly clear that many subsets of Treg cells exist, which have different functions and reside in different locations. Treg cell therapies may benefit from tailoring the selected subset to the tissue that must be protected as well as to characteristics of the immune response that must be suppressed, but little attention is given to this topic in current therapies.