Publications by authors named "R J Mount"
Intracranial electrical kilohertz stimulation has recently been shown to achieve similar therapeutic benefit as conventional frequencies around 140 Hz. However, it is unknown how kilohertz stimulation influences neural activity in the mammalian brain. Using cellular calcium imaging in awake mice, we demonstrate that intracranial stimulation at 1 kHz evokes robust responses in many individual neurons, comparable to those induced by conventional 40 and 140 Hz stimulation in both the hippocampus and sensorimotor cortex.
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- The Supplemental Nutrition Assistance Program (SNAP) supports food security for older adults, yet 60% of eligible seniors in Missouri do not participate due to various barriers.
- Focus group discussions revealed common challenges such as feelings of shame, difficulty accessing technology, and insufficient benefit amounts as food costs rise.
- Recommendations include simplifying the application process, creating the Elderly Simplified Application, and boosting education and outreach efforts to increase awareness of SNAP among older adults.
Background: Few studies have investigated optimal storage conditions or expiration dates for sublingual immunotherapy (SLIT) formulations prepared from glycerinated allergen extracts.
Hypothesis/objectives: The objective of this study was to compare concentrations of short ragweed major allergen (Amb a 1) and total protein in SLIT formulations stored at two different temperatures. It was hypothesised that protein concentrations would show greater decline over time in a formulation stored at room temperature (RT) than in one stored under refrigeration.
Voltage imaging with cellular specificity has been made possible by advances in genetically encoded voltage indicators. However, the kilohertz rates required for voltage imaging lead to weak signals. Moreover, out-of-focus fluorescence and tissue scattering produce background that both undermines the signal-to-noise ratio and induces crosstalk between cells, making reliable in vivo imaging in densely labeled tissue highly challenging.
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- Mutations in autism spectrum disorder (ASD) risk genes affect neural network dynamics, leading to abnormal behaviors.
- Researchers studied the hippocampal networks in transgenic mice lacking an ASD-risk gene, identifying significant learning and memory deficits tied to these mutations.
- Analysis revealed that while individual neuron excitability remained unchanged, the CA1 network in knockout mice was overly synchronized during movement, disrupting normal spatial memory functions and contributing to ASD-like behaviors.