Publications by authors named "R J Meijers"
Multiple endocrine neoplasia type 1 (MEN1) is a hereditary tumor syndrome characterized by endocrine tumors, typically from parathyroid, pancreatic, or anterior pituitary origin. In addition, benign cutaneous soft tissue tumors are prevalent in MEN1 patients. Although sarcomas have been reported in MEN1 patients it is unclear if these tumors should be considered as part of the MEN1 syndrome.
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- Antibodies are important in scientific research, but many of them haven't been properly tested, making some research results questionable.
- There have been efforts to fix this problem, especially for antibodies that work with human proteins.
- The article suggests ways that different people and organizations, like researchers and universities, can help make sure future studies with antibodies are more reliable.
Cell-surface receptors can be difficult to express and purify for structural and biochemical studies due to low expression levels, misfolding, aggregation, and instability. Cell-surface receptor ectodomains are more amenable to large-scale production, but this requires designing and testing various truncation constructs. However, since each protein is unique, testing these constructs individually for many targets is a time-consuming process.
View Article and Find Full Text PDFIntegrins are cell surface receptors that mediate the interactions of cells with their surroundings and play essential roles in cell adhesion, migration, and homeostasis. Eight of the 24 integrins bind to the tripeptide Arg-Gly-Asp (RGD) motif in their extracellular ligands, comprising the RGD-binding integrin subfamily. Despite similarity in recognizing the RGD motif and some redundancy, these integrins can selectively recognize RGD-containing ligands to fulfill specific functions in cellular processes.
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- Melanocytic neoplasms with spitzoid histomorphology are tricky to classify without genetic testing, as traditional methods often provide unclear results.
- The Idylla GeneFusion Assay has been compared to the Archer fusion assay on its ability to detect certain gene fusions (ALK, pan-NTRK, RET, and ROS1), showing promising results with a 75% sensitivity and 100% specificity in analyzing 147 samples.
- Idylla is effective with isolated RNA and could be a useful initial screening tool for spitzoid melanocytic tumors, even though it may not replace more detailed tests like the Archer assay.