Publications by authors named "R J McQuade"
Background: Multimorbidity and patient complexity are increasing, yet undergraduate medical education curricula remain dominated by single disease frameworks, where students are often shielded from exposure to this complexity. Why this shielding continues to occur is understandable; however, this may leave graduates feeling underprepared for real-world practice. This study aimed to explore medical students' experiences of encountering, managing and dealing with complexity and to provide informed recommendations for integrating complexity into clinical teaching.
View Article and Find Full Text PDFGlobal average life expectancy has steadily increased over the last several decades and is projected to reach ~ 77 years by 2050. As it stands, the number of people > 60 years currently outnumbers children younger than 5 years, and by 2050, it is anticipated that the global population of people aged > 60 years will double, surpassing 2.1 billion.
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- The study aimed to evaluate the efficacy, safety, and tolerability of brexpiprazole for treating borderline personality disorder (BPD), as no approved drugs exist for this condition.* -
- In a randomized, double-blind trial, 324 adult patients with BPD were given either brexpiprazole or a placebo for 11 weeks, but the results showed no significant difference between the two groups on the primary outcome measure.* -
- While brexpiprazole did not meet the primary study goal, some positive signals for efficacy were noted at different time points, indicating that further research is needed, especially considering safety concerns like akathisia (restlessness) reported more frequently in brexpipraz
Bacterial cancer therapy (BCT) is a promising therapeutic for solid tumours. Salmonella enterica Typhimurium (STm) is well-studied amongst bacterial vectors due to advantages in genetic modification and metabolic adaptation. A longstanding paradox is the redundancy of T cells for treatment efficacy; instead, STm BCT depends on innate phagocytes for tumour control.
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- Legumain is an enzyme linked to inflammation and has been found to activate a receptor that causes pain in oral cancer, but its role in the gastrointestinal tract, particularly in colon health, is less understood.
- In studies using a specialized probe, researchers found that legumain is activated in specific colon cells during acute colitis, but inhibiting or removing legumain did not affect colon cell permeability or colitis symptoms in mouse models.
- Advanced proteomic analyses revealed potential interactions and substrates of legumain, suggesting possible functions in the gut and its contribution to the development of colorectal cancer amidst inflammation.