Publications by authors named "R J Marino"
Background Aims: Patients with hepatocellular carcinoma (HCC) meeting UNOS-downstaging (DS) criteria have excellent post-liver transplantation (LT) outcomes. Studies on HCC beyond UNOS-DS criteria ("All-comers" (AC)) have been limited by small sample size and short follow-up time, prompting this analysis.
Approach Results: 326 patients meeting UNOS-DS and 190 meeting AC criteria from 9 LT centers across 5 UNOS regions were enrolled from 2015 to 2023 and prospectively followed.
Background: This research explores complement activation products involvement and risk and protective polymorphisms in the complement alternative pathway genes in Shiga toxin-associated hemolytic uremic syndrome (STEC-HUS) pathogenesis.
Methods: We analyzed the levels of complement activation products, C3a, C5a and soluble C5b-9 (sC5b-9) and plasma concentrations of Factor H (FH) and FH-related protein 1 (FHR-1) in 44 patients with STEC-HUS, 12 children with STEC-positive diarrhea (STEC-D), and 72 healthy controls (HC). STEC-HUS cases were classified as "severe" or "non-severe".
Immune checkpoint inhibitors (ICIs) have revolutionised the treatment landscape for advanced hepatocellular carcinoma (HCC). The combination of atezolizumab and bevacizumab has demonstrated efficacy, establishing a new standard of care for advanced HCC. Neoadjuvant studies have shown promising results with high response rates, increasing research into ICIs' role.
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- The study examines how energy moves within plasma turbulence, focusing on its effects on heating in space and astrophysical environments.
- It suggests that magnetic reconnection plays a key role in energy transfer, facilitating both downward transfer to smaller scales and upward transfer to larger scales.
- Utilizing advanced simulations, the research provides solid evidence that magnetic reconnection initiates this complex dual energy transfer process.
Article Synopsis
- The study investigates the relationship between plasma BDNF levels and DNA methylation of BDNF promoters in individuals suffering from work-related stress disorders and compares these findings to healthy controls.
- Results indicate that patients with major depressive disorder (MDD) and adjustment disorders (AD) have higher levels of pBDNF compared to controls, with MDD patients showing lower pBDNF levels than AD patients.
- The findings suggest that altered BDNF levels and promoter methylation may play significant roles in stress-related disorders, hinting at a protective response in some cases, but also a potential vulnerability to severe illness under stress.