Characterizing protein interactions employing a genome-wide siRNA cellular phenotyping screen.

Characterizing the activating and inhibiting effect of protein-protein interactions (PPI) is fundamental to gain insight into the complex signaling system of a human cell. A plethora of methods has been suggested to infer PPI from data on a large scale, but none of them is able to characterize the effect of this interaction. Here, we present a novel computational development that employs mitotic phenotypes of a genome-wide RNAi knockdown screen and enables identifying the activating and inhibiting effects of PPIs.

An aneurysm clipping training module for the neurosurgical training simulator NeuroSim.

Having introduced NeuroSim, the prototype of a neurosurgical training simulator at MMVR18, we present our first medical training module. NeuroSim is based on virtual reality and uses real-time algorithms for simulating tissue. It provides a native interface by using a real surgical microscope and original instruments.

NeuroSim--the prototype of a neurosurgical training simulator.

We present NeuroSim, the prototype of a training simulator for open surgical interventions on the human brain. The simulator is based on virtual reality and uses real-time simulation algorithms to interact with models generated from MRT- or CT-datasets. NeuroSim provides a native interface by using a real surgical microscope and original instruments tracked by a combination of inertial measurement units and optical tracking.

EYESi ophthalmoscope - a simulator for indirect ophthalmoscopic examinations.

We present a training simulator for indirect ophthalmoscopy. An optical tracking system is used to reconstruct the position of a lens mockup and a model of the patient's face. Refraction and illumination are computed in real-time and displayed on a head-mounted display using augmented reality.

Development of a guiding endoscopy simulator.

Endoscopy simulators get more and more common for the training of physicians. It is important to make simulation as realistic as possible by providing optical, acoustical and haptical feedback. The haptic display of our simulator EndoSim allows applying active forces to all degrees of freedom and moving to defined positions.