Publications by authors named "R J M Castelein"
Purpose: To assess the benefits of using the touched vertebra (TV) rule in Lenke classification for thoracic curves of adolescent idiopathic scoliosis (AIS).
Methods: A total of 141 AIS patients with thoracic curves determined by Suk classification were divided based on whether the lowest instrumented vertebra (LIV) matched the TV into groups of mTV (n = 84, LIV = TV), TV- (n = 21, LIV above TV), and TV+ (n = 36, LIV below TV) for 5-year follow-up. The radiological parameters were the central sacral vertical line (CSVL)-LIV distance, distal end vertebra rotation, coronal, and sagittal parameters.
Background: Scoliosis is a deformation of the spine and trunk that, in its more severe forms, creates a life-long burden of disease and requires intensive treatment. For its most prevalent form, adolescent idiopathic scoliosis, no underlying condition can be defined, and the pathomechanism appears to be multifactorial; however, it has been suggested that the biomechanics of the spine play a role. For nonidiopathic scoliosis, underlying conditions can be recognized, but what drives the deformity remains unclear.
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- - The study investigates the genetic relationship between Adolescent Idiopathic Scoliosis (AIS) and Schizophrenia (SCZ), particularly focusing on the 22q11.2 deletion syndrome, which greatly increases the risk for both conditions in adolescents.
- - Researchers utilized data from three genome-wide association studies (GWAS) to analyze single nucleotide polymorphisms (SNPs) linked to both AIS and SCZ, while also examining gene networks related to the 22q11.2 region.
- - Findings showed a significant genetic overlap between AIS and SCZ, with the most impactful SNPs forming a meaningful enrichment cluster, indicating a potential shared biological pathway.
Article Synopsis
- The study evaluates the effectiveness of AI models ChatGPT and Bard in generating structured abstracts for spine surgery, comparing them to human-written ones.
- The methodology involved analyzing 174 abstracts (60 human-written, 60 by ChatGPT, and 54 by Bard), focusing on compliance with journal guidelines, formatting, and content consistency.
- Results indicated ChatGPT performed better in meeting formatting guidelines, while Bard had higher adherence to word count requirements and showed greater similarity in content, suggesting differences in AI capabilities and implications for academic writing.
Introduction: Visualization of scoliosis typically requires ionizing radiation (radiography and CT) to visualize bony anatomy. MRI is often additionally performed to screen for neural axis abnormalities. We propose a 14-minutes radiation-free scoliosis-specific MRI protocol, which combines MRI and MRI-based synthetic CT images to visualize soft and osseous structures in one examination.
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