Publications by authors named "R J Litjens"
Article Synopsis
- - The study examined outbreaks of a zoonotic pathogen in pigs, focusing on 56 sampled animals to understand the disease's metabolic and physiological impacts, particularly in those showing neurological symptoms.
- - Key findings included altered blood chemistry in diseased pigs, such as increased pH and reduced levels of glucose and electrolytes compared to healthy controls, as well as a higher prevalence of specific bacterial serotypes in the neurologically affected pigs.
- - The results suggest genetic factors may contribute to disease susceptibility, as a greater proportion of sibling pigs showed signs of the disease, indicating a possible link between family associations and health outcomes in swine.
Background: Artificial intelligence (AI)-based mobile phone apps (mHealth) have the potential to streamline care for suspicious skin lesions in primary care. This study aims to investigate the conditions and feasibility of a study that incorporates an AI-based app in primary care and evaluates its potential impact.
Methods: We conducted a pilot feasibility study from November 22nd, 2021 to June 9th, 2022 with a mixed-methods design on implementation of an AI-based mHealth app for skin cancer detection in three primary care practices in the Netherlands (Rotterdam, Leiden and Katwijk).
In this paper, we focus on the link density in random geometric graphs (RGGs) with a distance-based connection function. After deriving the link density in D dimensions, we focus on the two-dimensional (2D) and three-dimensional (3D) space and show that the link density is accurately approximated by the Fréchet distribution, for any rectangular space. We derive expressions, in terms of the link density, for the minimum number of nodes needed in the 2D and 3D spaces to ensure network connectivity.
View Article and Find Full Text PDFSOX2 expression in the pathogenesis of premalignant lesions of the uterine cervix: its histo-topographical distribution distinguishes between low- and high-grade CIN.
Histochem Cell Biol
December 2022
SOX2 expression in high-grade cervical intraepithelial neoplasia (CIN3) and cervical squamous cell carcinoma is increased compared to that in the normal cervical epithelium. However, data on the expression and histological distribution of SOX2 in squamous epithelium during progression of CIN are largely lacking. We studied SOX2 expression throughout the epithelium in 53 cases of CIN1, 2, and 3.
View Article and Find Full Text PDFSalmonella in pigs is a concern for human foodborne salmonellosis. Dietary fungal fermented products, coated butyrate, and organic acids (OAs) may be promising control strategies. The objectives of this study were (i) to evaluate in vitro binding affinity of Salmonella enterica serovar Typhimurium (S.
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