Publications by authors named "R J Leach"
Article Synopsis
- - The population of Newfoundland and Labrador primarily descends from 18th-19th century settlers from England and Ireland, with genetic studies showing it's an isolated founder population with limited diversity.
- - A study analyzed 1,110 Y chromosomes and identified 160 distinct haplogroups, predominantly of the R1b type, mirroring the haplogroups found in English and Irish populations.
- - The research highlighted geographical and religious clustering within the population, indicating that historical settlement patterns and limited immigration have shaped the genetic structure of Newfoundland and Labrador.
Prostate cancer is a heterogeneous disease with a spectrum of pathology and outcomes ranging from indolent to lethal. Although there have been recent advancements in prognostic tissue biomarkers, limitations still exist. We leveraged matrix-assisted laser desorption/ionization imaging of formalin-fixed, paraffin embedded prostate cancer specimens to determine if N-linked glycans expressed in the extracellular matrix of lethal neuroendocrine prostate cancer were also expressed in conventional prostate adenocarcinomas that were associated with poor outcomes.
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- Researchers used matrix-assisted laser desorption/ionization mass spectrometry imaging to analyze prostate cancer tissues.
- The study identified key molecular features within the tissue matrix that could serve as early indicators of prostate cancer spread (metastasis).
- These findings suggest potential new avenues for predicting and possibly preventing the progression of prostate cancer.
The current study investigated the effectiveness of factual and narrative messages in promoting advocacy intentions among viewers of COVID-19 vaccination messaging. In an online posttest only experiment on Qualtrics online software, participants ( = 323) were randomly assigned to one of four conditions related to type of messaging (i.e.
View Article and Find Full Text PDFUpgrading of Grade Group 1 Prostate Cancer at Prostatectomy: Germline Risk Factors in a Prospective Cohort.
Cancer Epidemiol Biomarkers Prev
November 2024
Background: Localized prostate tumors show significant spatial heterogeneity, with regions of high-grade disease adjacent to lower grade disease. Consequently, prostate cancer biopsies are prone to sampling bias, potentially leading to underestimation of tumor grade. To study the clinical, epidemiologic, and molecular hallmarks of this phenomenon, we conducted a prospective study of grade upgrading: differences in detected prostate cancer grade between biopsy and surgery.
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