Publications by authors named "R J L Kandimalla"
Background: Remedial teaching is a tailored educational approach dedicated to enhancing the academic performance of students facing challenges within the curriculum. By identifying and addressing specific learning difficulties, it provides essential support and guidance to bring students closer to expected standards while preventing future setbacks. We hypothesize that underperforming medical students who receive daily, tailored remediation will demonstrate significant improvement in their formative and summative assessment scores in biochemistry.
View Article and Find Full Text PDF: Lung cancer is one of the deadliest cancers, and drug resistance complicates its treatment. Mahanine (MH), an alkaloid from has been known for its anti-cancer properties. However, its effectiveness and mechanisms in treating non-small cell lung cancer (NSCLC) remain largely unexplored.
View Article and Find Full Text PDFCancer remains a leading cause of mortality, with non-small cell lung cancer (NSCLC) being a primary contributor to cancer-related deaths. Traditional treatment strategies such as chemotherapy, radiation, and hormone therapy often present challenges, including severe side effects, drug resistance, and toxicity. Recent advancements in nanotechnology aim to enhance the effectiveness of cancer therapies by targeting drugs selectively and specifically to tumor cells.
View Article and Find Full Text PDFArticle Synopsis
- BMS-986365 is a novel oral treatment for metastatic castration-resistant prostate cancer (mCRPC), targeting the androgen receptor (AR) through a unique dual mechanism that both degrades and antagonizes it.
- In a Phase 1 clinical trial involving 95 patients, the drug was found to be well tolerated, with common but manageable side effects, and showed signs of effectiveness, particularly in patients who had not previously undergone chemotherapy.
- The primary goals of the study included assessing safety and determining the highest dose that could be tolerated, while key outcomes such as a significant drop in prostate-specific antigen levels and improved progression-free survival were also evaluated.
Background: Hypothyroidism is known to affect a wide range of physiological systems, including menstrual function, in women of reproductive age. This study aims to comprehensively analyze the association between hypothyroidism and menstrual irregularities in women attending a tertiary care center.
Methods: The study included 120 women aged 18-45 who presented with menstrual abnormalities.