Publications by authors named "R J Kinders"
Article Synopsis
- The study focuses on specific clusters of CD8+ T cells, categorized as CD8-NOS2+COX2+ and CD8-NOS2-COX2+, which play a significant role in the immune response to tumors.
- These unique cellular environments affect the spatial structure of CD8+ T cell interactions within tumors and can influence patient outcomes.
- The findings suggest that existing treatments, like NOS inhibitors and NSAIDs, could potentially target these cellular neighborhoods to improve cancer therapy.
Article Synopsis
- Immune therapy is becoming a key approach in cancer treatment, particularly for aggressive types like triple negative breast cancer (TNBC), where factors like COX2 limit treatment effectiveness.
- A study revealed that combining radiation with the anti-inflammatory drug indomethacin significantly boosted the immune response, reduced tumor growth, and lowered metastasis in mouse models of TNBC.
- The combination treatment led to better local control of tumors and increased survival rates by enhancing immune activity, suggesting that existing NSAIDs could improve the success of radiation therapy in cancer patients.
Estrogen receptor-negative (ER-) breast cancer is an aggressive breast cancer subtype with limited therapeutic options. Upregulated expression of both inducible nitric oxide synthase (NOS2) and cyclo-oxygenase (COX2) in breast tumors predicts poor clinical outcomes. Signaling molecules released by these enzymes activate oncogenic pathways, driving cancer stemness, metastasis, and immune suppression.
View Article and Find Full Text PDFA strong correlation between NOS2 and COX2 tumor expression and poor clinical outcomes in ER breast cancer has been established. However, the mechanisms of tumor induction of these enzymes are unclear. Analysis of The Cancer Genome Atlas (TCGA) revealed correlations between NOS2 and COX2 expression and Th1 cytokines.
View Article and Find Full Text PDFA strong correlation between NOS2 and COX2 tumor expression and poor clinical outcomes in ER-breast cancer has been established. However, mechanisms of tumor induction of these enzymes are unclear. Analysis of The Cancer Genome Atlas (TCGA) revealed correlations between NOS2 and COX2 expression and Th1 cytokines.
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