A high-throughput platform for single-molecule tracking identifies drug interaction and cellular mechanisms.

The regulation of cell physiology depends largely upon interactions of functionally distinct proteins and cellular components. These interactions may be transient or long-lived, but often affect protein motion. Measurement of protein dynamics within a cellular environment, particularly while perturbing protein function with small molecules, may enable dissection of key interactions and facilitate drug discovery; however, current approaches are limited by throughput with respect to data acquisition and analysis.

A mechanical comparison of the translational traction of female-specific and male soccer boots.

The studded outsole of a soccer boot provides additional traction to players to minimise the risk of slipping while performing high-speed manoeuvres. As excessive traction can lead to foot fixation and injury risk, there has been significant research surrounding the influence of stud configuration on the level of traction generated. This previous research, however, has predominately focused on the stud patterns, foot morphology and lower limb loading patterns of male players.

Protecting the profession: lessons from the recent physician scandals.

Sexual abuse scandals in recent years have eroded some of the trust that is foundational for the physician-patient relationship. A closer analysis of some of these stories of abuse from the standpoint of medical professionalism, primarily utilizing the example of Larry Nassar, DO, yields potential ways in which instances of abuse may be reduced or eliminated. The goal of this paper is to elicit lessons that can be learned from these tragic sequences of events so that physicians, healthcare institutions, physician practices, medical boards, and even patients themselves can introduce measures that help prevent future stories like these.

Effect of Soccer Boot Outsole Configuration on Translational Traction Across Both Natural and Artificial Playing Surfaces.

Background: Soccer boots are produced with different stud patterns and configurations to provide players with extra traction on specific surface types to minimize slipping and improve player performance. Excessive traction, however, can lead to foot fixation injuries, particularly anterior cruciate ligament tears.

Purpose/hypothesis: The purpose of this study was to explore the translational traction properties of 5 different outsole configurations moving in 4 different directions across both natural grass and artificial grass (AG) playing surfaces.

3D Kinematics of Male and Female Soccer Players for a Variety of Game-Specific Skills.

Soccer is played by a variety of individuals with varying abilities. The complicated lower limb movements involved within the game often lead to knee and ankle injuries, with anterior cruciate ligament injuries being the most severe with regard to rehabilitation time and ongoing health risks. This research explores the biomechanical kinematics of male and female soccer players on synthetic grass to determine whether trends in lower limb biomechanics over a variety of movements could explain injury risk.