Publications by authors named "R J Jankowski"
Background: Clinical trials have demonstrated the effectiveness of biologics in treating chronic rhinosinusitis with nasal polyps (CRSwNP). However, real-world evidence regarding patient outcomes and predictors of clinical response remains limited.
Methodology: In this multicentric 18-month follow-up study, 326 adult patients who initiated biologic therapy for severe uncontrolled CRSwNP were included.
Climate change and global warming necessitate the shift toward low-emission, carbon-free fuels. Although hydrogen boasts zero carbon content and high performance, its utilization is impeded by the complexities and costs involved in liquefaction, preservation, and transportation. Ammonia has emerged as a viable alternative that offers potential as a renewable energy storage medium and supports the global economy's decarbonization.
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- - The study evaluated the safety and effectiveness of iltamiocel, an autologous muscle cell therapy, for treating stress urinary incontinence (SUI) in women, comparing it to a placebo group.
- - Results showed no significant difference in the overall reduction of stress incontinence episodes between groups, but iltamiocel was more effective in women with previous SUI surgeries, indicating potential benefits for this specific population.
- - While the primary endpoint was not achieved, iltamiocel therapy was deemed safe, suggesting further research is needed for women with prior SUI surgery who lack effective treatment options.
Article Synopsis
- Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common condition affecting 2% of people, typically treated with corticosteroids and saline rinses, with surgery as an option for those who don't respond to medication.
- In France, two biologic treatments are available for severe cases that don’t improve after existing therapies or surgery, and a new study will evaluate the effectiveness and safety of these biologics in real-life settings.
- The BIOlogics in severe nasal POlyposis SurvEy (BIOPES) is a national, multicenter study aimed at understanding the impact of biologics on CRSwNP patients and gathering various clinical data to inform future treatments.
Background: Among all studies describing COVID-19 clinical features during the first wave of the pandemic, only a few retrospective studies have assessed the correlation between olfac-tory dysfunction (OD) and the evolution of disease severity. The main aim was to assess whether OD is a predictive factor of COVID-19 severity based on the patient's medical management (outpa-tient care, standard hospital admission, and ICU admission).
Methods: A national, prospective, mul-ticenter cohort study was conducted in 20 public hospitals and a public center for COVID-19 screen-ing.