Publications by authors named "R J Jankovic"
Tertiary Lymphoid Structures (TLS) are organized aggregates of immune cells such as T cells, B cells, and Dendritic Cells (DCs), as well as fibroblasts, formed postnatally in response to signals from cytokines and chemokines. Central to the function of TLS are DCs, professional antigen-presenting cells (APCs) that coordinate the adaptive immune response, and which can be classified into different subsets, with specific functions, and markers. In this article, we review current data on the contribution of different DC subsets to TLS function in cancer and autoimmunity, two opposite sides of the immune response.
View Article and Find Full Text PDFBackground: It is projected that, by 2040, the number of new cases of colorectal cancer (CRC) will increase to 3.2 million, and the number of deaths to 1.6 million, highlighting the need for prevention strategies, early detection and adequate follow-up.
View Article and Find Full Text PDFArticle Synopsis
- - Crohn's disease (CD) is a rising chronic inflammatory bowel condition that's tough to diagnose due to unclear criteria, often needing teamwork between doctors and pathologists.
- - The disease typically shows transmural inflammation and can include rare features like Schaumann bodies (SB), which are seldom found in CD cases (around 10%).
- - A case of a 4-year-old girl with severe symptoms led to the discovery of SB in her gastric mucosa, helping to confirm her diagnosis of early-onset CD and demonstrating the need to differentiate it from similar diseases.
The anti-inflammatory/immunomodulatory effects of L. (TM), a plant distributed in the Mediterranean region, have been insufficiently examined. The effects of the TM ethanol extract were tested in a rat collagen-induced arthritis (CIA) model of rheumatoid arthritis.
View Article and Find Full Text PDFAssessment of chemical-shift and diffusion-weighted magnetic resonance imaging in differentiating malignant and benign vertebral lesions in oncologic patients. A single institution experience.
Radiol Oncol
December 2024
Article Synopsis
- Two MRI techniques, CSI and DWI, were used to help tell apart cancerous and non-cancerous bone marrow lesions in patients with cancer.
- The study looked at 102 patients and found that cancerous lesions had higher SIR values and lower ADC values compared to benign ones, which helps doctors make better decisions.
- Using both CSI and DWI together made it even easier to tell the difference, reaching a very high level of accuracy in identifying the types of lesions.