Publications by authors named "R J J H van Son"
Background: Treatment for oral or oropharyngeal squamous cell carcinoma (O&OSCC) often leads to problems with speech articulation. Articulatory-kinematic data may be especially informative in designing new therapeutic approaches for individuals treated for these tumours.
Aims: To provide a systematic review of the literature assessing the articulatory-kinematic consequences of oral and oropharyngeal cancer treatment.
Article Synopsis
- This study explored the long-term effects of using a device (SEA2.0) for swallowing rehabilitation in individuals who have had their larynx removed (laryngectomized).
- Seventeen participants were evaluated six months after initial training, revealing that while some aspects of swallowing improved from the start of the study, there was a decline in swallowing capacity compared to an earlier assessment after a rest period.
- Overall, although the benefits of rehabilitation were still noticeable long-term, ongoing exercise may be necessary to maintain these improvements, indicating a need for further research on the best practices for sustaining swallowing function.
Objective: To assess the effectiveness of audiovisuals in providing pre-treatment information to patients with cancer. Following the Six Function Model of Medical Communication, we distinguish between immediate, intermediate, and long-term outcomes.
Methods: A systematic search was performed in five electronic databases for quantitative studies comparing the addition of audiovisuals with standard care or alternative interventions.
Autoimmune diseases, among the most common disorders of young adults, are mediated by genetic and environmental factors. Although CD4FOXP3 regulatory T cells (T) play a central role in preventing autoimmunity, the molecular mechanism underlying their dysfunction is unknown. Here, we performed comprehensive transcriptomic and epigenomic profiling of T in the autoimmune disease multiple sclerosis (MS) to identify critical transcriptional programs regulating human autoimmunity.
View Article and Find Full Text PDFA robust and stable carbonic anhydrase (CA) system is indispensable for effectively sequestering carbon dioxide to mitigate climate change. While microbial surface display technology has been employed to construct an economically promising cell-displayed CO-capturing biocatalyst, the displayed CA enzymes were prone to inactivation due to their low stability in harsh conditions. Herein, drawing inspiration from biomineralized diatom frustules, we artificially introduced biosilica shell materials to the CA macromolecules displayed on Escherichia coli surfaces.
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