B(CF)-Catalyzed Dehydrogenation of Pyrrolidines to Form Pyrroles.

Pyrroles are important -heterocycles found in medicines and materials. The formation of pyrroles from widely accessible pyrrolidines is a potentially attractive strategy but is an underdeveloped approach due to the sensitivity of pyrroles to the oxidative conditions required to achieve such a transformation. Herein, we report a catalytic approach that employs commercially available B(CF) in an operationally simple procedure that allows pyrrolidines to serve as direct synthons for pyrroles.

Evaluation of the prehospital use of a Valsalva assist device in the emergency treatment of supraventricular tachycardia (EVADE SVT): study protocol for a stepped wedge cluster randomised controlled trial.

Introduction: Patients with episodes of supraventricular tachycardia (SVT), a common heart arrhythmia, are often attended by ambulance services. International guidelines advocate treatment with the Valsalva manoeuvre (VM), but this simple physical treatment has a low success rate, with most patients requiring conveyance to hospital. The Valsalva Assist Device (VAD) is a simple device that might help practitioners and patients perform a more effective VM and reduce the need for patients to be taken to hospital.

Controlling the outcome of S2 reactions in ionic liquids: from rational data set design to predictive linear regression models.

Rate constants for a bimolecular nucleophilic substitution (SN2) process in a range of ionic liquids are correlated with calculated parameters associated with the charge localisation on the cation of the ionic liquid (including the molecular electrostatic potential). Simple linear regression models proved effective, though the interdependency of the descriptors needs to be taken into account when considering generality. A series of ionic liquids were then prepared and evaluated as solvents for the same process; this data set was rationally chosen to incorporate homologous series (to evaluate systematic variation) and functionalities not available in the original data set.

Resolving X-ray photoelectron spectra of ionic liquids with difference spectroscopy.

X-ray photoelectron spectroscopy (XPS) is a powerful element-specific technique to determine the composition and chemical state of all elements in an involatile sample. However, for elements such as carbon, the wide variety of chemical states produce complex spectra that are difficult to interpret, consequently concealing important information due to the uncertainty in signal identity. Here we report a process whereby chemical modification of carbon structures with electron withdrawing groups can reveal this information, providing accurate, highly refined fitting models far more complex than previously possible.

Correction: Rationalising the effects of ionic liquids on a nucleophilic aromatic substitution reaction.

Correction for 'Rationalising the effects of ionic liquids on a nucleophilic aromatic substitution reaction' by Rebecca R. Hawker et al., Org.