Publications by authors named "R J Hastie"
Background: Evidence suggests L-arginine may be effective at reducing pre-eclampsia and related outcomes. However, whether L-arginine can prevent or only treat pre-eclampsia, and thus the target population and timing of initiation, remains unknown.
Objectives: To evaluate the effects of L-arginine and L-citrulline (precursor of L-arginine) on the prevention and treatment of pre-eclampsia.
Objectives: To assess whether plasma concentrations of the circulating inflammatory proteins Interleukin-6 (IL-6), Vascular Cell Adhesion Molecule-1 (VCAM-1) and C-Reactive Protein (CRP) are increased in women with preeclampsia with end-organ complications, compared with women with preeclampsia without end-organ complications.
Study Design: We used samples from a large prospective biobank collection (Preeclampsia Obstetric Adverse Event biobank), and two large, randomized preeclampsia therapeutic treatment trials. All samples were collected in Cape Town, South Africa.
Background: Eclampsia is a serious pregnancy complication and is associated with cerebral edema and infarctions. However, the underlying pathophysiology of eclampsia remains poorly explored.
Objective: This study aimed to assess the pathophysiology of eclampsia using specialized magnetic resonance imaging to measure diffusion, perfusion, and vasospasm.
Article Synopsis
- Hypertensive disorders of pregnancy are a major cause of serious health issues for mothers and newborns, prompting a need for early identification of women at high risk to improve care and resource allocation.
- A systematic review found 110 studies involving over 506,000 women, but due to significant variability in tests and outcomes, most results were too diverse to combine effectively.
- Some predictors, like the sFlt-1/PlGF ratio, showed potential for forecasting risks, but they haven't been validated in external studies, highlighting a gap in reliable predictive tools for managing these conditions.