Cobalt Complexes with Aminophenolate Ligands: Spin Crossover and Ligand Versatility.

A search for switchable molecules has afforded a family of cobalt complexes featuring derivatives of 2-aminophenol: 4,6-di--butyl aminophenol (HL) and 2-anilino-4,6-di--butyl aminophenol (HL). The heteroleptic cobalt complexes incorporate a Metpa ligand (tpa = tris(2-pyridylmethyl)amine; = 0-3), which involves the methylation of the 6-position of the pyridine ring). Eight members of this family have been synthesized and characterized: [Co(HL)(tpa)](BPh) (), [Co(HL)(Metpa)](BPh) (), [Co(L)(Metpa)](BPh) (), [Co(HL)(Metpa)](BPh) (), [Co(L)(Metpa)](BPh) (), [Co(HL)(tpa)] (BPh)(ClO) (), [Co(L)(tpa)](BPh)(ClO) () and [Co(HL)(Metpa)](BPh) (), where the aminophenol-derived ligands are monoanionic in either the open shell radical iminosemiquinonate (L) or the closed shell protonated aminophenolate (HL).

Synthetic and theoretical study on novel N-ylidic complexes of mercury as new antibacterial agents.

The novel structure of Hg(II) complexes including the pyridinium ylide CHNCHC(O)CH-m-Br (Y) were synthesized and reported in this study. In the first step, the pyridinium salt CHNCHC(O)CH-m-Br (S) was produced by reacting 2,3'-dibromoactophenone and pyridine. then, treatment of S with KCO gave the related pyridinium ylide Y.

Phenotypic-Based Discovery and Exploration of a Resorufin Scaffold with Activity against Mycobacterium tuberculosis.

Tuberculosis remains a leading cause of death by infectious disease. The long treatment regimen and the spread of drug-resistant strains of the causative agent Mycobacterium tuberculosis (Mtb) necessitates the development of new treatment options. In a phenotypic screen, nitrofuran-resorufin conjugate 1 was identified as a potent sub-micromolar inhibitor of whole cell Mtb.

Predicting valence tautomerism in diverse cobalt-dioxolene complexes: elucidation of the role of ligands and solvent.

The ability of molecular switches to reversibly interconvert between different forms promises potential applications at the scale of single molecules up to bulk materials. One type of molecular switch comprises cobalt-dioxolene compounds that exhibit thermally-induced valence tautomerism (VT) interconversions between low spin Co(iii)-catecholate (LS-Co-cat) and high spin Co(ii)-semiquinonate (HS-Co-sq) forms. Two families of these compounds have been investigated for decades but have generally been considered separately: neutral [Co(diox)(sq)(NL)] and cationic [Co(diox)(NL)] complexes (diox = generic dioxolene, NL/NL = bidentate/tetradentate N-donor ancillary ligand).

Anticancer, antioxidant, and antimicrobial studies and molecular docking of a new hexanuclear Zn(II) complex, together with its X-ray crystal analysis.

A new hexanuclear Zn(II) complex with the ligand 2,2'-(piperazine-1,4-diyl)bis(ethan-1-amine), [LZn(OH)][ClO]·3MeOH·7HO, was synthesized. The crystal structure of this complex showed that each Zn atom is in a distorted tetrahedral coordination environment, surrounded by two nitrogen atoms from each ligand and two hydroxide groups, each of which bridges to another Zn atom. The anticancer activities of the ligand and its metal complex against the breast cancer cell line (MCF-7) indicated that the zinc complex had a greater anticancer activity.