Publications by authors named "R J Fitzpatrick"
Article Synopsis
- Climate change is causing shifts in animal habitats, particularly affecting the distribution of threatened marine species like whale sharks.
- Projections indicate that by 2100, whale sharks could lose more than 50% of their core habitat in some areas, with significant geographic shifts that could place them in closer proximity to large ships.
- The increase in whale shark interaction with shipping is expected to be dramatically higher under high emission scenarios compared to sustainable development, highlighting the urgency for better climate-threat predictions in conservation strategies for endangered marine life.
Vascular pathology is associated with cognitive impairment in diseases such as type 1 diabetes; however, how capillary flow is affected and the underlying mechanisms remain elusive. Here we show that capillaries in the diabetic mouse brain in both sexes are prone to stalling, with blocks consisting primarily of erythrocytes in branches off ascending venules. Screening for circulating inflammatory cytokines revealed persistently high levels of interleukin-10 (IL-10) in diabetic mice.
View Article and Find Full Text PDFEosinophils are a highly abundant cell type in the gastrointestinal tract during homeostatic conditions, where they have recently been reported to take on an activated phenotype following colonization by the bacterial microbiota. To date, there have been few studies investigating whether eosinophils respond to infection with enteric bacterial pathogens and/or investigating the requirements for eosinophils for effective bacterial pathogen control. In this study, we investigated the response of eosinophils to an acute enteric infection of mice with the bacterial pathogen serovar Typhimurium.
View Article and Find Full Text PDFThe frequency of unprovoked shark bites is increasing worldwide, leading to a growing pressure for mitigation measures to reduce shark-bite risk while maintaining conservation objectives. Personal shark deterrents are a promising and non-lethal strategy that can protect ocean users, but few have been independently and scientifically tested. In Australia, bull (Carcharhinus leucas), tiger (Galeocerdo cuvier), and white sharks (Carcharodon carcharias) are responsible for the highest number of bites and fatalities.
View Article and Find Full Text PDFBackground: In 2022, England embarked on an ambitious and innovative re-organisation to produce an integrated health and care system with a greater focus on improving population health. This study aimed to understand how nascent ICSs are developing and to identify the key challenges and enablers to integration.
Methods: Four ICSs participated in the study between November 2021 and May 2022.