Publications by authors named "R J Fass"

Article Synopsis
  • Gastroesophageal reflux disease (GERD) is a long-term condition where stomach contents flow back into the esophagus, potentially causing serious issues like Barrett esophagus and esophageal adenocarcinoma, with proton pump inhibitors (PPIs) being the main treatment despite needing daily use.
  • Noncontinuous therapy methods for treating GERD include on-demand medication and intermittent use of antireflux drugs, which can be preferable for patients due to convenience and cost savings while addressing concerns over long-term PPI use.
  • Potassium-competitive acid blockers (P-CABs) show promise for noncontinuous therapy of GERD due to their rapid effects and ease of use, although more research is needed to fully confirm their effectiveness compared to PP
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Article Synopsis
  • Noncardiac chest pain (NCCP) of esophageal origin affects over 80 million Americans each year and is influenced by various psychological disorders, which are found in up to 79% of affected patients.
  • Multiple psychological conditions such as depression, anxiety, and panic disorders may either trigger the chest pain or result from it, with mechanisms like cardiophobia and altered pain perception playing significant roles.
  • Cognitive behavioral therapy is identified as an effective treatment among various psychological therapies, emphasizing the need for more research and trained professionals to better manage this complex condition.
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Background: Diabetes Mellitus (DM) is known to induce a wide range of harmful effects on several organs, notably leading to ineffective esophageal motility (IEM). However, the relationship between DM and IEM is not fully elucidated. We aimed to determine the relationship between DM and IEM and to evaluate the impact of DM's end organ complications on IEM severity.

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Backgroud: The use of neuromodulators is prevalent in various functional gastrointestinal disease. However, data concerning the outcomes of these treatments in functional esophageal disorders (FED) remains limited and inadequate.

Aims: The aim of the present study is to examine the efficacy of central neuromodulators in FED.

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