Identifying barriers and opportunities to facilitate the uptake of whole genome sequencing in paediatric haematology and oncology practice.

Background: The clinical utility of whole genome sequencing (WGS) in paediatric cancer has been demonstrated in recent years. WGS has been routinely available in the National Health Service (NHS) England for all children with cancer in England since 2021, but its uptake has been variable geographically. To explore the underlying barriers to routine use of WGS in this population across England and more widely in the United Kingdom (UK) and the Republic of Ireland (ROI), a one-day workshop was held in Cambridge, United Kingdom in October 2022.

Early Intervention in Patients With Asymptomatic Severe Aortic Stenosis and Myocardial Fibrosis: The EVOLVED Randomized Clinical Trial.

Importance: Development of myocardial fibrosis in patients with aortic stenosis precedes left ventricular decompensation and is associated with an adverse long-term prognosis.

Objective: To investigate whether early valve intervention reduced the incidence of all-cause death or unplanned aortic stenosis-related hospitalization in asymptomatic patients with severe aortic stenosis and myocardial fibrosis.

Design, Setting, And Participants: This prospective, randomized, open-label, masked end point trial was conducted between August 2017 and October 2022 at 24 cardiac centers across the UK and Australia.

Reliability of the New Index of Global Food Quality and its relationship with sociodemographic variables and physical activity levels in the Chilean population.

Introduction: surveys play a crucial role in evaluating the quality of food in populations, especially in healthcare settings, helping identify important characteristics of food descriptions and improving efficiency in the collection and management of data in dietary surveys. Objective: the primary aim of this study was to analyze the internal consistency of the New Index of Global Food Quality (NIGFQ) instrument and assess its applicability to sociodemographic variables and levels of physical activity (IPAQ-S) in a specific region of Chile. Methods: a descriptive, comparative, and correlational study that utilizes the online platform of Google Forms for data collection using the New Index of Global Food Quality (NIGFQ) and IPAQ-S instruments, in addition to considering sociodemographic variables, in a sample of 1,331 participants from the metropolitan region of Chile.