Publications by authors named "R J Doyle"
Background: Individuals with dementia have communication limitations resulting from cognitive impairments that define the syndrome. Whereas there are numerous cognitive assessments for individuals with dementia, there are far fewer communication assessments. The Profiling Communication Ability in Dementia (P-CAD) was developed to address this gap.
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- Current methods for assessing disease severity and progression in Chronic Kidney Disease (CKD) are limited, prompting a study that highlights FERM-domain containing protein 3 (FRMD3) as a key candidate for further research.
- Using RNA sequencing, the study analyzed CKD biopsies and correlated gene expression with clinical indicators, discovering 93 genes related to CKD severity and progression, including FRMD3.
- Further investigation into FRMD3 showed its importance in cell structure and health, with knockdown experiments indicating its role in preventing cell death and maintaining cell junction integrity.
Background: The role of computed tomography (CT) before lumbar puncture (LP) is unclear, with limited evidence for a causal link between LP and cerebral herniation or for the ability of CT to identify individuals at risk of herniation. The risks of LP delay or deferral are potentially greater in high-HIV prevalence, resource-limited settings; we analyzed data from such a setting to determine the impact of CT on time to LP and treatment, as well as mortality.
Methods: Adults with suspected central nervous system (CNS) infection were enrolled prospectively into the Botswana National Meningitis Survey between 2016 and 2019.
Prevalence of and potential risk factors for multiple resistance to acaricides in Rhipicephalus (Boophilus) microplus ticks: A survey in the state of Rio Grande Do Sul, Brazil.
Med Vet Entomol
October 2024
Article Synopsis
- * A study in Rio Grande do Sul, Brazil, revealed that 98% of cattle farms had ticks resistant to multiple acaricides, with 71% of samples resistant to all six tested compounds.
- * Factors such as the use of injectable acaricides, frequent treatments, and larger herd sizes were linked to increased resistance rates, indicating a serious challenge for effective tick management.
Article Synopsis
- Tuberculous meningitis (TBM) is a major health issue in Botswana, especially linked to high HIV rates, and prior to 2016, TB testing was limited to mycobacterial cultures, making diagnosis difficult.
- The introduction of the GeneXpert platform significantly improved TB-specific investigations in cerebrospinal fluid samples, increasing from 4.5% to 29% from 2016 to 2022, as access to testing became more widespread.
- Despite a decline in total CSF samples analyzed, the proportion of microbiologically confirmed TBM cases rose slightly, indicating that better testing methods are leading to more accurate diagnoses in remote healthcare settings.