Publications by authors named "R J DeVita"
Article Synopsis
- Scientists discovered a new way to study how proteins in the brain can be changed after they're made, specifically focusing on a type called "dopaminylation."
- They found over 1,500 proteins that have this change, many of which are important for sending signals in brain cells and helping with memory.
- One protein, called γCaMKII, plays a big role in helping neurons talk to each other and might be important for learning and adapting to new situations.
Article Synopsis
- Harmine, a key ingredient in the hallucinogenic drink Ayahuasca, raises questions about its psychoactive effects, maximum tolerated dose (MTD), and safety in humans when administered in pharmaceutical-grade form.
- A Phase 1 trial with 25 healthy adults tested varying doses of harmine hydrochloride (100-500 mg) to assess safety and potential psychoactivity, identifying the MTD as between 100 and 200 mg while noting mild to moderate gastrointestinal and neurological side effects.
- Results indicate that doses below 2.7 mg/kg of harmine HCl are generally safe with few adverse effects, while higher doses lead to more severe reactions and limited psychoactivity, marking this
Five hundred thirty-seven million people globally suffer from diabetes. Insulin-producing β cells are reduced in number in most people with diabetes, but most individuals still have some residual β cells. However, none of the many diabetes drugs in common use increases human β cell numbers.
View Article and Find Full Text PDFGlutaric Aciduria Type 1 (GA1) is a serious inborn error of metabolism with no pharmacological treatments. A novel strategy to treat this disease is to divert the toxic biochemical intermediates to less toxic or nontoxic metabolites. Here, we report a putative novel target, succinyl-CoA:glutarate-CoA transferase (SUGCT), which we hypothesize suppresses the GA1 metabolic phenotype through decreasing glutaryl-CoA and the derived 3-hydroxyglutaric acid.
View Article and Find Full Text PDFThe small molecule DYRK1A inhibitor, harmine, induces human beta cell proliferation, expands beta cell mass, enhances expression of beta cell phenotypic genes, and improves human beta cell function i and . It is unknown whether the "pro-differentiation effect" is a DYRK1A inhibitor class-wide effect. Here we compare multiple commonly studied DYRK1A inhibitors.
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