Publications by authors named "R J Darby"
Background: Financial exploitation vulnerability (FEV) denotes the risk for falling victim to financial fraud and older adults reportedly lose an estimated $36 billion annually to scams. Socioemotional and cognitive impairments are potential risk factors for FEV in older adults with dementia. The present study examines whether the socioemotional measures of sensitivity to unfairness and self-unawareness of socioemotional dysfunction and brain atrophy are associated with increased risk for FEV in Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD).
View Article and Find Full Text PDFIntroduction: Psychotropic medication (PM) use in behavioral-variant frontotemporal dementia (bvFTD) is higher than in other dementias. However, no information exists on whether PM use differs between sporadic and genetic bvFTD.
Methods: We analyzed data from sporadic and genetic bvFTD participants with PM prescriptions in the Advancing Research and Treatment in Frontotemporal Lobar Degeneration/Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects study.
Background: Antisocial behaviors occur in up to 91% of individuals with behavioral variant frontotemporal dementia (bvFTD). Prior work has shown that antisocial behaviors can be differentiated into aggressive and nonaggressive rule-breaking behavioral subtypes. Socioemotional dysfunction is common in bvFTD and unique compared to other types of dementia.
View Article and Find Full Text PDFBackground And Objectives: Frontotemporal lobar degeneration (FTLD) includes different clinical syndromes with distinct patterns of symptoms and neuroanatomical locations of neurodegeneration. However, FTLD is clinically heterogeneous (with overlapping symptoms across several domains) and neuroanatomically heterogeneous (with brain atrophy in different locations in different patients). Traditional methods struggle to fully account for this heterogeneity.
View Article and Find Full Text PDFArticle Synopsis
- Behavioral variant frontotemporal dementia (bvFTD) is characterized by a range of neuropsychiatric symptoms (NPS) that occur frequently both early and late in the illness, impacting emotional and behavioral aspects.
- A study involving 354 participants identified four main clusters of NPS—affective, disinhibited, compulsive, and psychosis—showing that some symptoms fluctuate while others remain stable over time.
- The findings suggest that NPS could be linked to specific brain network disruptions, providing insight for potential treatments, although the variability in symptoms indicates they may not be reliable indicators of disease progression.