Publications by authors named "R J Coakley"
Nontuberculous mycobacterium (NTM) infections are challenging to manage and are frequently non-responsive to aggressive but poorly-tolerated antibiotic therapies. Immunosuppressed lung transplant patients are susceptible to NTM infections and poor patient outcomes are common. Bacteriophages present an alternative treatment option and are associated with favorable clinical outcomes.
View Article and Find Full Text PDFIntroduction: The process of co-creation can enable more effective, agile and integrated healthcare solutions achieving outcomes that effectively translate to healthcare delivery. Collaborative knowledge generation is particularly important in fields such as pediatric chronic pain where there is a complex interplay between biological, social, environmental, emotional, familial and school factors. The co-creation initiative described here was designed to amplify the voices of youth with chronic pain and their families and a variety of key stakeholders and generate novel approaches to the management of chronic pediatric pain in the setting of the South Australian Pediatric Chronic Pain Service.
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- Proteases, particularly neutrophil elastase, activate the epithelial sodium channel (ENaC) and contribute to dehydration in the airways, which is a concern for lung health.
- This study investigates how higher levels of proteases in the airways of vapers affect ENaC activity and hydration by exposing human bronchial epithelial cultures to fluid from non-smokers, smokers, and vapers.
- Results showed that the airway surface liquid height decreased significantly in vapers and smokers, indicating airway dehydration, and similar effects were linked to e-liquid exposure, suggesting that vaping could lead to lung diseases similar to those caused by smoking.
Background: The gold standard of treatment for chronic pain is a multidisciplinary approach in which psychology plays a leading role, but many children and caregivers do not gain access to this treatment. The Comfort Ability Program (CAP) developed a CBT-oriented group intervention for adolescents and caregivers designed expressly to address access to evidence-based psychological care for pediatric chronic pain. Before the COVID-19 disruption of in-person services, the CAP workshop had been disseminated to a network of 21 children's hospitals across three countries.
View Article and Find Full Text PDFImportance: The COVID-19 pandemic led to the use of lung transplant as a lifesaving therapy for patients with irreversible lung injury. Limited information is currently available regarding the outcomes associated with this treatment modality.
Objective: To describe the outcomes following lung transplant for COVID-19-related acute respiratory distress syndrome or pulmonary fibrosis.