Publications by authors named "R J Chestnut"
Article Synopsis
- Penetrating crossbow injuries to the head are uncommon and lack a standardized treatment approach.
- Three cases were studied where patients with self-inflicted crossbow injuries had intact neurological functions.
- A multidisciplinary management plan led to the successful removal of the arrows, and all patients were discharged with minimal disability.
Preclinical pharmacokinetic (PK) assays are important to help evaluate the safety and efficacy of a potential biotherapeutic before clinical studies. The assay typically requires a biotherapeutic-specific reagent to minimize matrix effects especially when the host species are non-human primates such as cynomolgus monkeys and the biotherapeutic is a humanized monoclonal antibody (MAb). Recombinant humanized mAb 2H7 (rhuMAb2H7) binds to the extracellular domain of CD20 that is expressed on B cells and results in B cell depletion.
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