Publications by authors named "R J Capetola"
Article Synopsis
- Researchers studied the impact of long-term all-trans-retinoic acid (RA) treatment on skin cell formation in rhino mice by applying 0.005% RA topically for up to 26 weeks.
- After five weeks of treatment, changes included thickening of specific skin layers and increased production of certain keratins, while filaggrin levels decreased.
- After 26 weeks, although the overall structure of the skin remained similar to untreated controls, distinct biochemical changes suggested that RA modified the normal process of skin cell maturation, indicating that while RA boosts skin cell growth, it doesn't hinder differentiation as seen in lab tests.
A multiple immunodeficiency, involving antibody- and cell-mediated responses in 10 Chinese Shar-Pei (CSP) dogs is described. Abnormal levels of serum IgM and IgA in most cases, and IgG in fewer cases characterized the immunoglobulin deficiencies. Decreased in vitro proliferative responses of pokeweed mitogen (PWM)-stimulated peripheral blood mononuclear cells (PBMC) were found in nine cases.
View Article and Find Full Text PDFTepoxalin [5-(4-chlorophenyl)-N-hydroxy-(4-methoxyphenyl)-N-methyl-1H- pyrazole-3-propanamide] is a potent inhibitor of sheep seminal vesicle cyclooxygenase (CO) (IC50 = 4.6 microM), rat basophilic leukemia cell (RBL-1) lysate CO (IC50 = 2.85 microM) and CO from intact RBL-1 cells (IC50 = 4.
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- Guanine ribonucleosides, specifically 7-allyl-8-oxoguanosine (loxoribine), have the capability to activate NK cells and improve their response when used alongside IL-2 in generating LAK cells.
- Loxoribine enhances NK cell activity in murine spleen cells optimally at concentrations between 50 to 150 microM, peaking at around 10 hours but diminishing to baseline levels by 24 hours.
- When combined with a low dose of IL-2, loxoribine prolongs the NK cell activity and increases the expression of the IL-2 receptor, indicating that it might prime cytolytic precursor cells for a more effective response to IL-
Guanine ribonucleosides which have been substituted at the N7 and/or C8 positions have been shown previously to activate natural killer (NK) cells and to act as sparing agents for interleukin-2 (IL-2) in the in vitro generation of lymphokine activated killer (LAK) cells. In this paper we examined a disubstituted guanosine, 7-allyl-8-oxoguanosine (loxoribine), for the ability to activate NK cells and to interact with IL-2 in the generation of LAK cells in vivo. Following iv administration, loxoribine enhanced murine splenic NK activity in a dose-related fashion, with optimal responses occurring at 3 mg/mouse.
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