Publications by authors named "R J Cantrell"
Thrombin promotes the proliferation and function of CD8+ T cells. To test if thrombin prevents exhaustion and sustains antiviral T cell activity during chronic viral infection, we depleted the thrombin-precursor prothrombin to 10% of normal levels in mice prior to infection with the clone 13 strain of lymphocytic choriomeningitis virus. Unexpectedly, prothrombin insufficiency resulted in 100% mortality after infection that was prevented by depletion of CD8+ T cells, suggesting that reduced availability of prothrombin enhances virus-induced immunopathology.
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- - The study aimed to compare the types and rates of complications from the Port Delivery System (PDS) with other ocular implants that cross the sclera, focusing on long-term safety from clinical trials and real-world data.
- - A systematic literature review found reports from 16 clinical trials and 43 real-world studies, which detailed 30 complications associated with various ocular implants, highlighting a generally acceptable safety profile.
- - The rates of specific complications for the PDS were consistent with those of other ocular devices, suggesting similar long-term safety across these implant systems in ophthalmology.
Strategies to access the 1,4-diazepindiones heterocyclic core of the TAN-1057 family of natural products revealed a successful gold-catalyzed hydroamination of yneamide tethered amines. The precursor amino-yneamides are derived from easily accessible 1,2-diamines and alkynoic acids and are efficiently cyclized to the corresponding diazepineones.
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